Lipid-based nanocomposites for mRNA delivery: Current trends and future challenges

Abstract

Lipid nanoparticles (LNPs) are critical for the efficient delivery and intracellular transport of mRNA. They have recently been recognized as essential components of COVID-19 mRNA vaccines. Recent vaccinations have demonstrated the significant of lipid-based nanocomposite in the positive and effective delivery of mRNA therapies. These nanocomposites boost mRNA's efficacy by improving stability, biological uptake, and targeted delivery. We examine how lipid-based mRNA delivery methods are still being developed.