1 Advancements in nanoparticle-supported Laccase immobilization:Offering promising solutions for water treatment 1 Water purification has become a crucial matter in various societies. Increasing demand for water treatment is a constant challenge in the field of water treatment. Nowadays enzyme immobilization plays a crucial role in the realm of water cleansing. Also, laccase is the most common enzyme used in this context. Laccase is an enzyme that has gained popularity in various water treatment applications due to its ability to degrade organic pollutants and contaminants. It can be used in combination with different materials, including nanoparticles, to enhance its performance in water purification processes. Laccase is known for its effectiveness in breaking down a wide range of organic compounds, making it a valuable tool in the field of water refinement and environmental remediation. This study aims to delve into current knowledge about the role of nanoparticles supported in laccase immobilization for water purification. Our exploration method describes the use of metal-based, magnetic, carbon-based, and other nanoparticle supports along with novel methods including cross-linking, covalent binding, encapsulation, adsorption, and layer-by-layer assembly used in laccase immobilization. Results reveal the effectiveness of diverse nanoparticles in enhancing laccase stability and activity. In conclusion underscores the potential of nanoparticle-supported laccase immobilization as a sustainable solution for water treatment, offering improved enzyme performance and reusability. 159 178 Sogand Bahadori Department of Chemistry, Kerman Branch, Islamic Azad University Iran Sogolbahadori@gmail.com Maryam Azimpour Hospital of Shahid Ayatollah Dastgheib, Shiraz University of Medical Science Iran info@jourcc.com Laccase immobilization Nanoparticle-supported materials Metal-based materials Magnetic nanomaterials Carbon-based nanomaterials Immobilization methods Water treatment Article2.pdf [1] M. Alcalde, Laccases: biological functions, molecular structure and industrial applications, Industrial Enzymes: structure, function and applications, Springer 2007, pp. 461-476.##[2] S.F.F. Zofair, S. Ahmad, M.A. Hashmi, S.H. Khan, M.A. Khan, H. 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