1 An overview of the development of composites containing Mg and Zn for drug delivery https://jourcc.com/index.php/jourcc/article/view/jcc244 10.29252/jcc.2.4.4 20.1001.1.26765837.2020.2.5.4.8 1 Drug delivery is known as the administration of drugs using suitable vehicle for achieving effective treatment with no unwanted effects. In recent years, various composite materials have been developed and evaluated for being used in different biomedical fields such as wound dressings, cardiac prosthesis, tissue engineering, and drug delivery. Zinc is the second most available element after Fe in our body. Nanoparticles based on metal oxides, such as zinc oxides and Zn-containing composites, can be considered as viable platforms for some biomedical uses, especially for drug delivery applications. Mg composite biomaterials are also suggested for diverse biomedical applications due to their good mechanical properties, biocompatibility, and bioactivity. This paper highlights applications of zinc and magnesium-based composites in development of drug delivery systems. 193 204 Firooze Niazvand Abadan Faculty of Medical Sciences Iran info@jourcc.com Amir Cheshmi Babol Noshirvani University of Technology Iran amir_cheshomi@yahoo.com Maryam Zand Alzahra University Iran info@jourcc.com Reyhaneh NasrAzadani Isfahan University of Medical Science Iran info@jourcc.com Beena Kumari Indira Gandhi Universit India info@jourcc.com Ali Raza Shanghai Jiaotong University China info@jourcc.com Shima Nasibi Shiraz University Iran info@jourcc.com Drug delivery Biomedical application Zinc oxide composite Mg composites Article4.pdf [1] G. Tiwari, R. Tiwari, B. Sriwastawa, L. Bhati, S. Pandey, P. Pandey, S.K. Bannerjee, Drug delivery systems: An updated review, International journal of pharmaceutical investigation 2(1) (2012) 2. ## [2] Z. Goudarzi, A. Ijadi, A. Bakhtiari, S. Eskandarinezhad, N. Azizabadi, M.A. Jazi, Sr-doped bioactive glasses for biological applications, Journal of Composites and Compounds 2(3) (2020) 105-109. ## [3] X. Zhang, M. Cresswell, Inorganic controlled release technology, Inorg. Control. Release Technol. (2016). ## [4] J.-H. Kang, M.-H. Chun, M.-S. Cho, Y.-B. Kwon, J.-C. Choi, D.-W. Kim, C.- W. Park, E.-S. Park, Preparation and characterization of metformin hydrochloride controlled-release tablet using fatty acid coated granules, Drug Development and Industrial Pharmacy 46(5) (2020) 852-860. ## [5] C.J. Grande, F.G. Torres, C.M. Gomez, M.C. Bañó, Nanocomposites of bacterial cellulose/hydroxyapatite for biomedical applications, Acta Biomaterialia 5(5) (2009) 1605-1615. ## [6] J.P. Jose, S. Thomas, J. Kuruvilla, S. Malhotra, K. Goda, M.S. Sreekala, Advances in polymer composites: macro-and microcomposites—state of the art, new challenges, and opportunities, Polymer Composites; Wiley: Weinheim, Germany 1 (2012) 3-16. ## [7] H. Ullah, F. Wahid, H.A. Santos, T. Khan, Advances in biomedical and pharmaceutical applications of functional bacterial cellulose-based nanocomposites, Fig. 4. Preparation of composite scaffolds by the space holder technique.200 F. Niazvand et al. / Journal of Composites and Compounds 2 (2020) 193-204 Carbohydrate polymers 150 (2016) 330-352. ## [8] F. Sharifanjazi, A.H. Pakseresht, M.S. Asl, A. Esmaeilkhanian, H.W. Jang, M. Shokouhimehr, Hydroxyapatite consolidated by zirconia: applications for dental implant, Journal of Composites and Compounds 2(1) (2020) 26-34. ## [9] L. Bazli, B. Eftekhari Yekta, A. Khavandi, Preparation and Characterization of Sn-Containing Glasses for Brachytherapy Applications, Transactions of the Indian Ceramic Society 76(4) (2017) 242-246. ## [10] Y. Kameshima, H. Sasaki, T. Isobe, A. Nakajima, K. Okada, Synthesis of composites of sodium oleate/Mg–Al-ascorbic acid-layered double hydroxides for drug delivery applications, International journal of pharmaceutics 381(1) (2009) 34-39. ## [11] M. Abniki, A. Moghimi, F. Azizinejad, Fabrication of bionanocomposite based on LDH using biopolymer of gum arabic and chitosan-coating for sustained drug-release, Journal of the Serbian Chemical Society 85(5) (2020). ## [12] M. Abniki, A. Moghimi, F. Azizinejad, Synthesis of calcium‐layered double hydroxide based nanohybrid for controlled release of an anti‐inflammatory drug, Journal of the Chinese Chemical Society (2020). ## [13] W.-H. Lu, K.-D. Li, C.-H. Lu, L.G. Teoh, W.H. Wu, Y.C. Shen, Synthesis and characterization of mesoporous SiO2–CaO–P2O5 bioactive glass by sol–gel process, Materials transactions 54(5) (2013) 791-795. ## [14] J. Andersson, S. Areva, B. Spliethoff, M. Lindén, Sol–gel synthesis of a multifunctional, hierarchically porous silica/apatite composite, Biomaterials 26(34) (2005) 6827-6835. ## [15] S.P. Hudson, R.F. Padera, R. Langer, D.S. Kohane, The biocompatibility of mesoporous silicates, Biomaterials 29(30) (2008) 4045-4055. ## [16] X. Li, X. Wang, H. Chen, P. Jiang, X. Dong, J. Shi, Hierarchically porous bioactive glass scaffolds synthesized with a PUF and P123 cotemplated approach, Chemistry of Materials 19(17) (2007) 4322-4326. ## [17] A. López-Noriega, D. Arcos, I. Izquierdo-Barba, Y. Sakamoto, O. Terasaki, M. Vallet-Regí, Ordered mesoporous bioactive glasses for bone tissue regeneration, Chemistry of Materials 18(13) (2006) 3137-3144. ## [18] X. Yan, X. Huang, C. Yu, H. Deng, Y. Wang, Z. Zhang, S. Qiao, G. Lu, D. Zhao, The in-vitro bioactivity of mesoporous bioactive glasses, Biomaterials 27(18) (2006) 3396-3403. ## [19] X. Yan, C. Yu, X. Zhou, J. Tang, D. Zhao, Highly ordered mesoporous bioactive glasses with superior in vitro bone‐forming bioactivities, Angewandte Chemie International Edition 43(44) (2004) 5980-5984. ## [20] M. Vašák, D.W. Hasler, Metallothioneins: new functional and structural insights, Current opinion in chemical biology 4(2) (2000) 177-183. ## [21] M.F. Heragh, S. Eskandarinezhad, A. Dehghan, Ni-Cu matrix composite reinforced with CNTs: preparation, characterization, wear and corrosion behavior, inhibitory effects, Journal of Composites and Compounds 2(4) (2020) 123-128. ## [22] C.T. Chasapis, A.C. Loutsidou, C.A. Spiliopoulou, M.E. Stefanidou, Zinc and human health: an update, Archives of toxicology 86(4) (2012) 521-534. ## [23] E. Alhava, H. Olkkonen, J. Puittinen, V. Nokso-Koivisto, Zinc content of human cancellous bone, Acta Orthopaedica Scandinavica 48(1) (1977) 1-4. ## [24] H. Kim, S. Mondal, S. Bharathiraja, P. Manivasagan, M.S. Moorthy, J. Oh, Optimized Zn-doped hydroxyapatite/doxorubicin bioceramics system for efcient drug delivery and tissue engineering application, Ceramics International 44(6) (2018) 6062-6071. ## [25] Y. Su, I. Cockerill, Y. Wang, Y.-X. Qin, L. Chang, Y. Zheng, D. Zhu, Zincbased biomaterials for regeneration and therapy, Trends in biotechnology 37(4) (2019) 428-441. ## [26] Z. Gao, D. Zhang, X. Li, S. Jiang, Q. Zhang, Current status, opportunities and challenges in chemical conversion coatings for zinc, Colloids and Surfaces A: Physicochemical and Engineering Aspects 546 (2018) 221-236. ## [27] S. Parveen, R. Misra, S.K. Sahoo, Nanoparticles: a boon to drug delivery, therapeutics, diagnostics and imaging, Nanomedicine: Nanotechnology, Biology and Medicine 8(2) (2012) 147-166. ## [28] H.M. Xiong, ZnO nanoparticles applied to bioimaging and drug delivery, Advanced Materials 25(37) (2013) 5329-5335. ## [29] Z.Y. Zhang, Y.D. Xu, Y.Y. Ma, L.L. Qiu, Y. Wang, J.L. Kong, H.M. Xiong, Biodegradable ZnO@ polymer core–shell nanocarriers: pH‐triggered release of doxorubicin in vitro, Angewandte Chemie 125(15) (2013) 4221-4225. ## [30] G. Song, Control of biodegradation of biocompatable magnesium alloys, Corrosion science 49(4) (2007) 1696-1701. ## [31] A.H. Shahbaz, M. Esmaeilian, R. NasrAzadani, K. Gavanji, The effect of MgF2 addition on the mechanical properties of hydroxyapatite synthesized via powder metallurgy, Journal of Composites and Compounds 1(1) (2019) 18-24. ## [32] S. Nasibi, K. Alimohammadi, L. Bazli, S. Eskandarinezhad, A. Mohammadi, N. Sheysi, TZNT alloy for surgical implant applications: A systematic review, Journal of Composites and Compounds 2(3) (2020) 62-68. ## [33] R. Erbel, C. Di Mario, J. Bartunek, J. Bonnier, B. de Bruyne, F.R. Eberli, P. Erne, M. Haude, B. Heublein, M. Horrigan, Temporary scaffolding of coronary arteries with bioabsorbable magnesium stents: a prospective, non-randomised multicentre trial, The Lancet 369(9576) (2007) 1869-1875. ## [34] M. Haude, R. Erbel, P. Erne, S. Verheye, H. Degen, D. Böse, P. Vermeersch, I. Wijnbergen, N. Weissman, F. Prati, Safety and performance of the drug-eluting absorbable metal scaffold (DREAMS) in patients with de-novo coronary lesions: 12 month results of the prospective, multicentre, frst-in-man BIOSOLVE-I trial, The Lancet 381(9869) (2013) 836-844. ## [35] M. Haude, H. Ince, A. Abizaid, R. Toelg, P.A. Lemos, C. von Birgelen, E.H. Christiansen, W. Wijns, F.-J. Neumann, C. Kaiser, Safety and performance of the second-generation drug-eluting absorbable metal scaffold in patients with de-novo coronary artery lesions (BIOSOLVE-II): 6 month results of a prospective, multicentre, non-randomised, frst-in-man trial, The Lancet 387(10013) (2016) 31-39. ## [36] B. Heublein, R. Rohde, V. Kaese, M. Niemeyer, W. Hartung, A. Haverich, Biocorrosion of magnesium alloys: a new principle in cardiovascular implant technology?, Heart 89(6) (2003) 651-656. ## [37] H. Li, H. Zhong, K. Xu, K. Yang, J. Liu, B. Zhang, F. Zheng, Y. Xia, L. Tan, D. Hong, Enhanced efcacy of sirolimus-eluting bioabsorbable magnesium alloy stents in the prevention of restenosis, Journal of Endovascular Therapy 18(3) (2011) 407-415. ## [38] R. Waksman, R. Erbel, C. Di Mario, J. Bartunek, B. de Bruyne, F.R. Eberli, P. Erne, M. Haude, M. Horrigan, C. Ilsley, Early-and long-term intravascular ultrasound and angiographic fndings after bioabsorbable magnesium stent implantation in human coronary arteries, JACC: Cardiovascular Interventions 2(4) (2009) 312-320. ## [39] R. Waksman, R. Pakala, P.K. Kuchulakanti, R. Baffour, D. Hellinga, R. Seabron, F.O. Tio, E. Wittchow, S. Hartwig, C. Harder, Safety and efcacy of bioabsorbable magnesium alloy stents in porcine coronary arteries, Catheterization and Cardiovascular Interventions 68(4) (2006) 607-617. ## [40] E. Wittchow, N. Adden, J. Riedmüller, C. Savard, R. Waksman, M. Braune, Bioresorbable drug-eluting magnesium-alloy scaffold: design and feasibility in a porcine coronary model, EuroIntervention 8(12) (2013) 1441-1450. ## [41] P. Zartner, R. Cesnjevar, H. Singer, M. Weyand, First successful implantation of a biodegradable metal stent into the left pulmonary artery of a preterm baby, Catheterization and Cardiovascular Interventions 66(4) (2005) 590-594. ## [42] M. Haude, H. Ince, A. Abizaid, R. Toelg, P.A. Lemos, C. von Birgelen, E.H. Christiansen, W. Wijns, F.-J. Neumann, C. Kaiser, Sustained safety and performance of the second-generation drug-eluting absorbable metal scaffold in patients with de novo coronary lesions: 12-month clinical results and angiographic fndings of the BIOSOLVE-II frst-in-man trial, European heart journal 37(35) (2016) 2701-2709. ## [43] M. Diba, O.-M. Goudouri, F. Tapia, A.R. Boccaccini, Magnesium-containing bioactive polycrystalline silicate-based ceramics and glass-ceramics for biomedical applications, Current opinion in solid state and materials science 18(3) (2014) 147-167. ## [44] Y. Bi, Y. Zheng, Y. Li, Microstructure and mechanical properties of sintered porous magnesium using polymethyl methacrylate as the space holder, Materials Letters 161 (2015) 583-586. ## [45] H. Bakhsheshi-Rad, E. Hamzah, M.P. Staiger, G.J. Dias, Z. Hadisi, M. Saheban, M. Kashefan, Drug release, cytocompatibility, bioactivity, and antibacterial activity of doxycycline loaded Mg-Ca-TiO2 composite scaffold, Materials and Design 139 (2018) 212-221. ## [46] K.K. Jain, Drug delivery systems-an overview, Drug delivery systems, Springer2008, pp. 1-50. ## [47] M. Arefan, M. Hojjati, I. Tajzad, A. Mokhtarzade, M. Mazhar, A. Jamavari, A review of Polyvinyl alcohol/Carboxiy methyl cellulose (PVA/CMC) composites for various applications, Journal of Composites and Compounds 2(3) (2020) 69- 76. ## [48] P. Abasian, M. Radmansouri, M.H. Jouybari, M.V. Ghasemi, A. Mohammadi, M. Irani, F.S. Jazi, Incorporation of magnetic NaX zeolite/DOX into the PLA/chitosan nanofbers for sustained release of doxorubicin against carcinoma cells death in vitro, International journal of biological macromolecules 121 (2019) 398-406. ## [49] H. Derendorf, L.J. Lesko, P. Chaikin, W.A. Colburn, P. Lee, R. Miller, R. Powell, G. Rhodes, D. Stanski, J. Venitz, Pharmacokinetic/pharmacodynamic modeling in drug research and development, The Journal of Clinical Pharmacology 40(12) (2000) 1399-1418. ## [50] S. Gopi, A. Amalraj, N.P. Sukumaran, J.T. Haponiuk, S. Thomas, Biopolymers and their composites for drug delivery: a brief review, Macromolecular Symposia, Wiley Online Library, 2018, p. 1800114. ## [51] G.R. Matzke, G.R. Aronoff, A.J. Atkinson Jr, W.M. Bennett, B.S. Decker, K.-U. Eckardt, T. Golper, D.W. Grabe, B. Kasiske, F. Keller, Drug dosing consideration in patients with acute and chronic kidney disease—a clinical update fromF. Niazvanda et al. / Journal of Composites and Compounds 2 (2020) 193-204 201 Kidney Disease: Improving Global Outcomes (KDIGO), Kidney international 80(11) (2011) 1122-1137. ## [52] M.J. Munoz-Davila, Role of old antibiotics in the era of antibiotic resistance. Highlighted nitrofurantoin for the treatment of lower urinary tract infections, Antibiotics 3(1) (2014) 39-48. ## [53] J.J. De Waele, S. Carrette, M. Carlier, V. Stove, J. Boelens, G. Claeys, I. Leroux-Roels, E. Hoste, P. Depuydt, J. Decruyenaere, Therapeutic drug monitoring-based dose optimisation of piperacillin and meropenem: a randomised controlled trial, Intensive care medicine 40(3) (2014) 380-387. ## [54] S.K. Bardal, J.E. Waechter, D.S. Martin, Applied pharmacology, Elsevier Health Sciences2011. ## [55] W. Brand, M.E. Schutte, G. Williamson, J.J. van Zanden, N.H. Cnubben, J.P. Groten, P.J. van Bladeren, I.M. Rietjens, Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients, Biomedicine and pharmacotherapy 60(9) (2006) 508-519. ## [56] A.H. Chow, H.H. Tong, P. Chattopadhyay, B.Y. Shekunov, Particle engineering for pulmonary drug delivery, Pharmaceutical research 24(3) (2007) 411-437. ## [57] S. Amirhossein, A.-B. Aydin, Z. Habib, Polaroid-PET: a PET scanner with detectors ftted with polaroids for fltering unpolarized optical photons: a Monte Carlo simulation study, Physics in Medicine and Biology (2020). ## [58] A. Sanaat, H. Zaidi, Depth of interaction estimation in a preclinical PET scanner equipped with monolithic crystals coupled to SiPMs using a deep neural network, Applied Sciences 10(14) (2020) 4753. ## [59] A. Sanaat, H. Arabi, M.R. Ay, H. Zaidi, Novel preclinical PET geometrical concept using a monolithic scintillator crystal offering concurrent enhancement in spatial resolution and detection sensitivity: a simulation study, Physics in Medicine and Biology 65(4) (2020) 045013. ## [60] A. Sanaat, H. Arabi, I. Mainta, V. Garibotto, H. Zaidi, Projection-space implementation of deep learning-guided low-dose brain PET imaging improves performance over implementation in image-space, Journal of Nuclear Medicine (2020) jnumed. 119.239327. ## [61] N. Kamaly, B. Yameen, J. Wu, O.C. Farokhzad, Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release, Chemical reviews 116(4) (2016) 2602-2663. ## [62] J. Daraei, Production and characterization of PCL (Polycaprolactone) coated TCP/nanoBG composite scaffolds by sponge foam method for orthopedic applications, Journal of Composites and Compounds 2(1) (2020) 45-50. ## [63] X. Huang, S. Wu, X. Ke, X. Li, X. Du, Phosphonated pillar ## [5] arene-valved mesoporous silica drug delivery systems, ACS Applied Materials and Interfaces 9(23) (2017) 19638-19645. ## [64] N.G. Kotla, B. Chandrasekar, P. Rooney, G. Sivaraman, A. Larrañaga, K.V. Krishna, A. Pandit, Y. Rochev, Biomimetic lipid-based nanosystems for enhanced dermal delivery of drugs and bioactive agents, ACS Biomaterials Science and Engineering 3(7) (2017) 1262-1272. ## [65] A. Kazemzadeh, H. Kazemzadeh, Determination of Hg2+ by Diphenylcarbazone Compound in Polymer Film, Journal of Composites and Compounds 1(1) (2019) 30-35. ## [66] A. Nouri, B. Faraji Dizaji, N. Kianinejad, A. Jafari Rad, S. Rahimi, M. Irani, F. Sharifan Jazi, Simultaneous linear release of folic acid and doxorubicin from ethyl cellulose/chitosan/g‐C3N4/MoS2 core‐shell nanofbers and its anticancer properties, Journal of Biomedical Materials Research Part A (2020). ## [67] D. Liu, F. Yang, F. Xiong, N. Gu, The smart drug delivery system and its clinical potential, Theranostics 6(9) (2016) 1306. ## [68] Z. Wang, Y. Duan, Y. Duan, Application of polydopamine in tumor targeted drug delivery system and its drug release behavior, Journal of Controlled Release 290 (2018) 56-74. ## [69] J. Ma, N. Zhao, D. Zhu, Endothelial cellular responses to biodegradable metal zinc, ACS biomaterials science and engineering 1(11) (2015) 1174-1182. ## [70] F.S. Jazi, N. Parvin, M. Rabiei, M. Tahriri, Z.M. Shabestari, A.R. Azadmehr, Effect of the synthesis route on the grain size and morphology of ZnO/Ag nanocomposite, Journal of Ceramic Processing Research 13(5) (2012) 523-526. ## [71] J. Jiang, J. Pi, J. Cai, The advancing of zinc oxide nanoparticles for biomedical applications, Bioinorganic chemistry and applications 2018 (2018). ## [72] Z. Zeng, X. Fang, W. Miao, Y. Liu, T. Maiyalagan, S. Mao, Electrochemically Sensing of Trichloroacetic Acid with Iron(II) Phthalocyanine and Zn-Based Metal Organic Framework Nanocomposites, ACS Sensors 4(7) (2019) 1934-1941. ## [73] W. Liu, Y. Pan, W. Xiao, H. Xu, D. Liu, F. Ren, X. Peng, J. Liu, Recent developments on zinc (ii) metal–organic framework nanocarriers for physiological pH-responsive drug delivery, MedChemComm 10(12) (2019) 2038-2051. ## [74] K. Dong, Y. Zhang, L. Zhang, Z. Wang, J. Ren, X. Qu, Facile preparation of metal− organic frameworks-based hydrophobic anticancer drug delivery nanoplatform for targeted and enhanced cancer treatment, Talanta 194 (2019) 703-708. ## [75] M. Zamani, M. Rostami, M. Aghajanzadeh, H. Kheiri Manjili, K. Rostamizadeh, H. Danafar, Mesoporous titanium dioxide@ zinc oxide–graphene oxide nanocarriers for colon-specifc drug delivery, Journal of Materials Science 53(3) (2018) 1634-1645. ## [76] J.W. Rasmussen, E. Martinez, P. Louka, D.G. Wingett, Zinc oxide nanoparticles for selective destruction of tumor cells and potential for drug delivery applications, Expert opinion on drug delivery 7(9) (2010) 1063-1077. ## [77] V. Karpina, V. Lazorenko, C. Lashkarev, V. Dobrowolski, L. Kopylova, V. Baturin, S. Pustovoytov, A.J. Karpenko, S. Eremin, P. Lytvyn, Zinc oxide–analogue of GaN with new perspective possibilities, Crystal Research and Technology: Journal of Experimental and Industrial Crystallography 39(11) (2004) 980-992. ## [78] X. Huang, X. Zheng, Z. Xu, C. Yi, Zno-based nanocarriers for drug delivery application: From passive to smart strategies, International journal of pharmaceutics 534(1-2) (2017) 190-194. ## [79] A.J. Rad, Synthesis of copper oxide nanoparticles on activated carbon for pollutant removal in Tartrazine structure, Journal of Composites and Compounds 2(3) (2020) 99-104. ## [80] A. Moghanian, A. Ghorbanoghli, M. Kazem‐Rostami, A. Pazhouheshgar, E. Salari, M. Saghaf Yazdi, T. Alimardani, H. Jahani, F. Sharifan Jazi, M. Tahriri, Novel antibacterial Cu/Mg‐substituted 58S‐bioglass: Synthesis, characterization and investigation of in vitro bioactivity, International Journal of Applied Glass Science 11(4) (2020) 685-698. ## [81] F. Sharifanjazi, M. Moradi, A. Abouchenari, A.H. Pakseresht, A. Esmaeilkhanian, M. Shokouhimehr, M.S. Asl, Effects of Sr and Mg dopants on biological and mechanical properties of SiO2–CaO–P2O5 bioactive glass, Ceramics International (2020). ## [82] S. Ni, L. Chou, J. Chang, Preparation and characterization of forsterite (Mg- 2SiO4) bioceramics, Ceramics International 33(1) (2007) 83-88. ## [83] N. Sezer, Z. Evis, S.M. Kayhan, A. Tahmasebifar, M. Koç, Review of magnesium-based biomaterials and their applications, Journal of Magnesium and Alloys 6(1) (2018) 23-43. ## [84] A. Bordbar-Khiabani, B. Yarmand, M. Mozafari, Emerging magnesium-based biomaterials for orthopedic implantation, Thomas Telford Ltd, 2019. ## [85] Z. Wu, T. Tang, H. Guo, S. Tang, Y. Niu, J. Zhang, W. Zhang, R. Ma, J. Su, C. Liu, In vitro degradability, bioactivity and cell responses to mesoporous magnesium silicate for the induction of bone regeneration, Colloids and Surfaces B: Biointerfaces 120 (2014) 38-46. ## [86] A. Bigham, S.A. Hassanzadeh-Tabrizi, M. Rafenia, H. Salehi, Ordered mesoporous magnesium silicate with uniform nanochannels as a drug delivery system: The effect of calcination temperature on drug delivery rate, Ceramics International 42(15) (2016) 17185-17191. ## [87] M. Vallet-Regi, Bio-ceramics with clinical applications, John Wiley and Sons2014. ## [88] P. Wu, D.W. Grainger, Drug/device combinations for local drug therapies and infection prophylaxis, Biomaterials 27(11) (2006) 2450-2467. ## [89] H. Dong, Q. Li, C. Tan, N. Bai, P. Cai, Bi-directional controlled release of ibuprofen and Mg2+ from magnesium alloys coated by multifunctional composite, Materials Science and Engineering: C 68 (2016) 512-518. ## [90] J. Tian, S. Shen, C. Zhou, X. Dang, Y. Jiao, L. Li, S. Ding, H. Li, Investigation of the antimicrobial activity and biocompatibility of magnesium alloy coated with HA and antimicrobial peptide, Journal of Materials Science: Materials in Medicine 26(2) (2015) 66. ## [91] J. Zhang, Z. Wen, M. Zhao, G. Li, C. Dai, Effect of the addition CNTs on performance of CaP/chitosan/coating deposited on magnesium alloy by electrophoretic deposition, Materials Science and Engineering: C 58 (2016) 992-1000. ## [92] A. Morawska-Chochół, P. Domalik-Pyzik, J. Chłopek, B. Szaraniec, J. Sterna, M. Rzewuska, M. Boguń, R. Kucharski, P. Mielczarek, Gentamicin release from biodegradable poly-l-lactide based composites for novel intramedullary nails, Materials Science and Engineering: C 45 (2014) 15-20. ## [93] A. Kazemzadeh, M.A. Meshkat, H. Kazemzadeh, M. Moradi, R. Bahrami, R. Pouriamanesh, Preparation of graphene nanolayers through surfactant-assisted pure shear milling method, Journal of Composites and Compounds 1(1) (2019) 25-30. ## [94] W.E. Teo, S. Ramakrishna, A review on electrospinning design and nanofbre assemblies, Nanotechnology 17(14) (2006) R89. ## [95] L.A. Mercante, V.P. Scagion, F.L. Migliorini, L.H. Mattoso, D.S. Correa, Electrospinning-based (bio) sensors for food and agricultural applications: A review, TrAC Trends in Analytical Chemistry 91 (2017) 91-103. ## [96] M. Jiménez, C. Abradelo, J. San Román, L. Rojo, Bibliographic review on the state of the art of strontium and zinc based regenerative therapies. Recent developments and clinical applications, Journal of materials chemistry B 7(12) (2019)202 F. Niazvand et al. / Journal of Composites and Compounds 2 (2020) 193-204 1974-1985. ## [97] T.J. Sill, H.A. Von Recum, Electrospinning: applications in drug delivery and tissue engineering, Biomaterials 29(13) (2008) 1989-2006. ## [98] Y. Qian, Solvothermal Synthesis of Nanocrystalline III–V Semiconductors, Advanced Materials 11(13) (1999) 1101-1102. ## [99] C. Wang, Z.-X. Deng, Y. Li, The synthesis of nanocrystalline anatase and rutile titania in mixed organic media, Inorganic Chemistry 40(20) (2001) 5210-5214. ## [100] K. Kaviyarasu, E. Manikandan, P. Paulraj, S. Mohamed, J. Kennedy, One dimensional well-aligned CdO nanocrystal by solvothermal method, Journal of alloys and compounds 593 (2014) 67-70. ## [101] C.-S. Kim, B.K. Moon, J.-H. Park, S. Tae Chung, S.-M. Son, Synthesis of nanocrystalline TiO2 in toluene by a solvothermal route, Journal of Crystal Growth 254(3) (2003) 405-410. ## [102] M. Kang, Synthesis of Fe/TiO2 photocatalyst with nanometer size by solvothermal method and the effect of H 2O addition on structural stability and photodecomposition of methanol, Journal of Molecular Catalysis A: Chemical 197(1) (2003) 173-183. ## [103] S. Yin, Y. Fujishiro, J. Wu, M. Aki, T. Sato, Synthesis and photocatalytic properties of fbrous titania by solvothermal reactions, Journal of Materials Processing Technology 137(1-3) (2003) 45-48. ## [104] S.M. Gupta, M. Tripathi, A review on the synthesis of TiO2 nanoparticles by solution route, Central European Journal of Chemistry 10(2) (2012) 279-294. ## [105] F.L. Theiss, G.A. Ayoko, R.L. Frost, Synthesis of layered double hydroxides containing Mg2+, Zn2+, Ca2+ and Al3+ layer cations by co-precipitation methods—A review, Applied Surface Science 383 (2016) 200-213. ## [106] M. Bukhtiyarova, A review on effect of synthesis conditions on the formation of layered double hydroxides, Journal of Solid State Chemistry 269 (2019) 494-506. ## [107] V. Solovov, N. Nikolenko, V. Kovalenko, V. Kotok, A. Burkov, D. Kondrat’ev, O. Chernovа, S. Zhukovin, Synthesis of Ni (II)-Ti (IV) layered double hydroxides using coprecipitation at high supersaturation method, ARPN Journal of Engineering and Applied Sciences 13(24) (2018) 9652-9656. ## [108] X. Duan, D.G. Evans, Layered double hydroxides, Springer Science and Business Media2006. ## [109] H.W. Olfs, L.O. Torres-Dorante, R. Eckelt, H. Kosslick, Comparison of different synthesis routes for Mg–Al layered double hydroxides (LDH): Characterization of the structural phases and anion exchange properties, Applied Clay Science 43(3) (2009) 459-464. ## [110] L. Bazli, M. Siavashi, A. Shiravi, A review of carbon nanotube/TiO2 composite prepared via sol-gel method, Journal of Composites and Compounds 1(1) (2019) 1-9. ## [111] A. Bakhtiari, A. Cheshmi, M. Naeimi, S.M. Fathabad, M. Aliasghari, A.M. Chahardehi, S. Hassani, V. Elhami, Synthesis and characterization of the novel 80S bioactive glass: bioactivity,‎ biocompatibility, cytotoxicity, Journal of Composites and Compounds 2(4) (2020) 110-114. ## [112] L. Armelao, D. Barreca, M. Bertapelle, G. Bottaro, C. Sada, E. Tondello, A sol–gel approach to nanophasic copper oxide thin flms, Thin Solid Films 442(1) (2003) 48-52. ## [113] F.S. Jazi, N. Parvin, M. Tahriri, M. Alizadeh, S. Abedini, M. Alizadeh, The relationship between the synthesis and morphology of SnO2-Ag2O nanocomposite, Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry 44(5) (2014) 759-764. ## [114] M. Alizadeh, F. Sharifanjazi, E. Haghshenasjazi, M. Aghakhani, L. Rajabi, Production of nanosized boron oxide powder by high-energy ball milling, Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry 45(1) (2015) 11-14. ## [115] L.S. Cividanes, T.M. Campos, L.A. Rodrigues, D.D. Brunelli, G.P. Thim, Review of mullite synthesis routes by sol–gel method, Journal of Sol-Gel Science and Technology 55(1) (2010) 111-125. ## [116] M. Gonçalves, Sol-gel silica nanoparticles in medicine: A natural choice. Design, synthesis and products, Molecules 23(8) (2018) 2021. ## [117] S. Devaraju, K. Krishnadevi, E. Naveena, M. Alagar, Eco-friendly fully bio-based polybenzoxazine-silica hybrid materials by sol–gel approach, Polymer Bulletin (2020) 1-10. ## [118] H. Böttcher, P. Slowik, W. Süß, Sol-gel carrier systems for controlled drug delivery, Journal of sol-gel science and technology 13(1-3) (1998) 277-281. ## [119] M. Catauro, E. Tranquillo, F. Barrino, I. Blanco, F. Dal Poggetto, D. Naviglio, Drug release of hybrid materials containing Fe (II) citrate synthesized by sol-gel technique, Materials 11(11) (2018) 2270. ## [120] Y. Ding, W. Li, A. Correia, Y. Yang, K. Zheng, D. Liu, D.W. Schubert, A.R. Boccaccini, H.A. Santos, J.A. Roether, Electrospun polyhydroxybutyrate/poly (ε-caprolactone)/Sol–gel-derived silica hybrid scaffolds with drug releasing function for bone tissue engineering applications, ACS applied materials and interfaces 10(17) (2018) 14540-14548. ## [121] M. Catauro, F. Barrino, G. Dal Poggetto, M. Milazzo, I. Blanco, S.V. Ciprioti, Structure, drug absorption, bioactive and antibacterial properties of sol-gel SiO2/ ZrO 2 materials, Ceramics International (2020). ## [122] S.K. Sahoo, S. Barik, G. Dehury, S. Dhala, S. Kanungo, B.B. Barik, K.K. Puhan, Evaluation of controlled release theophylline microspheres prepared with cellulose acetate using solvent evaporation method, Tropical Journal of Pharmaceutical Research 10(2) (2011). ## [123] S. Jaraswekin, S. Prakongpan, R. Bodmeier, Effect of poly (lactide-co-glycolide) molecular weight on the release of dexamethasone sodium phosphate from microparticles, Journal of microencapsulation 24(2) (2007) 117-128. ## [124] S. Freitas, H.P. Merkle, B. Gander, Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology, Journal of Controlled Release 102(2) (2005) 313-332. ## [125] J. Emami, H. Hamishehkar, A.R. Najafabadi, K. Gilani, M. Minaiyan, H. Mahdavi, A. Nokhodchi, A Novel Approach to Prepare Insulin-Loaded Poly (Lactic-Co-Glycolic Acid) Microcapsules and the Protein Stability Study, Journal of Pharmaceutical Sciences 98(5) (2009) 1712-1731. ## [126] M.L. Manca, Chitosan and PLGA microspheres as drug delivery system against pulmonary mycobacteria infections, (2007). ## [127] M. Hoppel, D. Mahrhauser, C. Stallinger, F. Wagner, M. Wirth, C. Valenta, Natural polymer‐stabilized multiple water‐in‐oil‐in‐water emulsions: a novel dermal drug delivery system for 5‐fluorouracil, Journal of Pharmacy and Pharmacology 66(5) (2014) 658-667. ## [128] H. Yang, Y. Hao, Q. Liu, Z. Mi, Z. Wang, L. Zhu, Q. Feng, N. Hu, Preparation and in vitro study of hydrochloric norvancomycin encapsulated poly (d, l-lactide-co-glycolide, PLGA) microspheres for potential use in osteomyelitis, Artifcial cells, nanomedicine, and biotechnology 45(7) (2017) 1326-1330. ## [129] M. Li, O. Rouaud, D. Poncelet, Microencapsulation by solvent evaporation: State of the art for process engineering approaches, International Journal of Pharmaceutics 363(1) (2008) 26-39. ## [130] W.M. Obeidat, Recent patents review in microencapsulation of pharmaceuticals using the emulsion solvent removal methods, Recent patents on drug delivery and formulation 3(3) (2009) 178-192. ## [131] Y. Maa, C. Hsu, Effect of primary emulsions on microsphere size and protein-loading in the double emulsion process, Journal of microencapsulation 14(2) (1997) 225-241. ## [132] D. Noviendri, Microencapsulation of Fucoxanthin by Water-in-Oil-in-Water (W/O/W) Double Emulsion Solvent Evaporation Method: A Review, Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology 9(3) (2014). ## [133] Y.-Y. Yang, T.-S. Chung, N.P. Ng, Morphology, drug distribution, and in vitro release profles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method, Biomaterials 22(3) (2001) 231-241. ## [134] R. Zhang, L. Gao, Preparation of nanosized titania by hydrolysis of alkoxide titanium in micelles, Materials research bulletin 37(9) (2002) 1659-1666. ## [135] A.S. Narang, D. Delmarre, D. Gao, Stable drug encapsulation in micelles and microemulsions, International journal of pharmaceutics 345(1-2) (2007) 9-25. ## [136] M.A. Malik, M.Y. Wani, M.A. Hashim, Microemulsion method: A novel route to synthesize organic and inorganic nanomaterials: 1st Nano Update, Arabian Journal of Chemistry 5(4) (2012) 397-417. ## [137] S.F. Chin, A. Azman, S.C. Pang, Size Controlled Synthesis of Starch Nanoparticles by a Microemulsion Method, Journal of Nanomaterials 2014 (2014) 763736. ## [138] H. Liu, J. Mei, Y. Xu, L. Tang, D. Chen, Y. Zhu, S. Huang, T.J. Webster, H. Ding, Improving The Oral Absorption Of Nintedanib By A Self-Microemulsion Drug Delivery System: Preparation And In Vitro/In Vivo Evaluation, International Journal of Nanomedicine 14 (2019) 8739. ## [139] M.B. de Jesus, A. Radaic, I.S. Zuhorn, E. de Paula, Microemulsion extrusion technique: a new method to produce lipid nanoparticles, Journal of nanoparticle research 15(10) (2013) 1960. ## [140] S.P. Callender, J.A. Mathews, K. Kobernyk, S.D. Wettig, Microemulsion utility in pharmaceuticals: Implications for multi-drug delivery, International journal of pharmaceutics 526(1-2) (2017) 425-442. ## [141] B. Yan, Y. Gu, J. Zhao, Y. Liu, L. Wang, Y. Wang, Self-microemulsion Technology for Water-insoluble Drug Delivery, Current Nanoscience 15(6) (2019) 576- 588. ## [142] S.M. Dizaj, F. Lotfpour, M. Barzegar-Jalali, M.-H. Zarrintan, K. Adibkia, Physicochemical characterization and antimicrobial evaluation of gentamicin-loaded CaCO 3 nanoparticles prepared via microemulsion method, Journal of Drug Delivery Science and Technology 35 (2016) 16-23.F. Niazvanda et al. / Journal of Composites and Compounds 2 (2020) 193-204 203 ## [143] M.N. Kelchen, N.K. Brogden, In vitro skin retention and drug permeation through intact and microneedle pretreated skin after application of propranolol loaded microemulsions, Pharmaceutical research 35(12) (2018) 228. ## [144] L. Huang, J. Wu, M. Liu, L. Mao, H. Huang, Q. Wan, Y. Dai, Y. Wen, X. Zhang, Y. Wei, Direct surface grafting of mesoporous silica nanoparticles with phospholipid choline-containing copolymers through chain transfer free radical polymerization and their controlled drug delivery, Journal of colloid and interface science 508 (2017) 396-404. ## [145] L.J. Min, T.Y.S. Edgar, Z. Zicheng, Y.W. Yee, Chapter 6 - Biomaterials for Bioprinting, in: L.G. Zhang, J.P. Fisher, K.W. Leong (Eds.), 3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine, Academic Press2015, pp. 129-148. ## [146] Z. Shi, C. Yang, R. Li, L. Ruan, Microwave thermal-triggered drug delivery using thermosensitive peptide-coated core–shell mesoporous silica nanoparticles, Journal of Materials Science 55(14) (2020) 6118-6129. ## [147] R.E. Mardziah, T.W. Wong, Effects of microwave on drug-release responses of spray-dried alginate microspheres, Drug development and industrial pharmacy 36(10) (2010) 1149-1167. ## [148] T. Wong, Use of microwave in processing of drug delivery systems, Current Drug Delivery 5(2) (2008) 77-84. ## [149] H. Qiu, B. Cui, W. Zhao, P. Chen, H. Peng, Y. Wang, A novel microwave stimulus remote controlled anticancer drug release system based on Fe3O4@ZnO@ mGd 2O3: Eu@P(NIPAm-co-MAA) multifunctional nanocarriers, Journal of Materials Chemistry B 3(34) (2015) 6919-6927. ## [150] J. Xu, X. Cheng, L. Tan, C. Fu, M. Ahmed, J. Tian, J. Dou, Q. Zhou, X. Ren, Q. Wu, Microwave responsive nanoplatform via P-selectin mediated drug delivery for treatment of hepatocellular carcinoma with distant metastasis, Nano letters 19(5) (2019) 2914-2927. ## [151] S. Miyazaki, H. Aoyama, N. Kawasaki, W. Kubo, D. Attwood, In situ-gelling gellan formulations as vehicles for oral drug delivery, Journal of Controlled release 60(2-3) (1999) 287-295. ## [152] Y. Wu, Y. Liu, X. Li, D. Kebebe, B. Zhang, J. Ren, J. Lu, J. Li, S. Du, Z. Liu, Research progress of in-situ gelling ophthalmic drug delivery system, Asian Journal of Pharmaceutical Sciences 14(1) (2019) 1-15. ## [153] M. Agrawal, S. Saraf, S. Saraf, S.K. Dubey, A. Puri, U. Gupta, P. Kesharwani, V. Ravichandiran, P. Kumar, V. Naidu, Stimuli-responsive In situ gelling system for nose-to-brain drug delivery, Journal of Controlled Release (2020). ## [154] K. Itoh, T. Hirayama, A. Takahashi, W. Kubo, S. Miyazaki, M. Dairaku, M. Togashi, R. Mikami, D. Attwood, In situ gelling pectin formulations for oral drug delivery at high gastric pH, International journal of pharmaceutics 335(1-2) (2007) 90-96. ## [155] T.N. Nimi, D.R. Manohar, An Overview on In-Situ Nasal Gel for Drug Delivery, Journal of Pharmaceutical Sciences and Research 11(7) (2019) 2585-2589. ## [156] S. Desai, S. Bolton, A floating controlled-release drug delivery system: in vitro-in vivo evaluation, Pharmaceutical research 10(9) (1993) 1321-1325. ## [157] Z. Shi, X. Chen, L. Zhang, S. Ding, X. Wang, Q. Lei, W. Fang, FA-PEG decorated MOF nanoparticles as a targeted drug delivery system for controlled release of an autophagy inhibitor, Biomaterials science 6(10) (2018) 2582-2590. ## [158] K. Neha, H.S. Nirmala, Insitu gelling system: A Review, J Drug Del and Therapeutics 4(4) (2014) 93-103. ## [159] P. Suradkar, R. Mishra, T. Nandgude, Overview on Trends in Development of Gastroretentive Drug Delivery System, Research Journal of Pharmacy and Technology 12(11) (2019) 5633-5640. ## [160] D. Bhowmik, R. Bhanot, D. Gautam, P. Rai, K. Kumar, Gastro Retentive Drug Delivery Systems-a Novel Approaches of Controlled Drug Delivery Systems, Research Journal of Science and Technology 10(2) (2018) 145-156. ## [161] S. Fredenberg, M. Wahlgren, M. Reslow, A. Axelsson, The mechanisms of drug release in poly (lactic-co-glycolic acid)-based drug delivery systems—a review, International journal of pharmaceutics 415(1-2) (2011) 34-52. ## [162] J. Panyam, V. Labhasetwar, Biodegradable nanoparticles for drug and gene delivery to cells and tissue, Advanced drug delivery reviews 55(3) (2003) 329-347. ## [163] Y. Ma, J.C. Pacan, Q. Wang, Y. Xu, X. Huang, A. Korenevsky, P.M. Sabour, Microencapsulation of bacteriophage Felix O1 into chitosan-alginate microspheres for oral delivery, Applied and environmental microbiology 74(15) (2008) 4799- 4805. ## [164] J. Trygg, E. Yildir, R. Kolakovic, N. Sandler, P. Fardim, Anionic cellulose beads for drug encapsulation and release, Cellulose 21(3) (2014) 1945-1955. ## [165] H. Bao, Y. Pan, Y. Ping, N.G. Sahoo, T. Wu, L. Li, J. Li, L.H. Gan, Chitosan‐ functionalized graphene oxide as a nanocarrier for drug and gene delivery, Small 7(11) (2011) 1569-1578. ## [166] S. Javanbakht, M. Pooresmaeil, H. Namazi, Green one-pot synthesis of carboxymethylcellulose/Zn-based metal-organic framework/graphene oxide bio-nanocomposite as a nanocarrier for drug delivery system, Carbohydrate Polymers 208 (2019) 294-301. ## [167] H.H.P. Duong, L.-Y.L. Yung, Synergistic co-delivery of doxorubicin and paclitaxel using multi-functional micelles for cancer treatment, International journal of pharmaceutics 454(1) (2013) 486-495. ## [168] F. Foroughi, S.A. Hassanzadeh-Tabrizi, A. Bigham, In situ microemulsion synthesis of hydroxyapatite-MgFe2O4 nanocomposite as a magnetic drug delivery system, Materials Science and Engineering: C 68 (2016) 774-779. ## [169] K. Drlica, Biology of bacterial deoxyribonucleic acid topoisomerases, Microbiological reviews 48(4) (1984) 273. ## [170] D. Pathania, D. Gupta, N. Kothiyal, G. Eldesoky, M. Naushad, Preparation of a novel chitosan-g-poly (acrylamide)/Zn nanocomposite hydrogel and its applications for controlled drug delivery of ofloxacin, International journal of biological macromolecules 84 (2016) 340-348. ## [171] S. Das, A. Chaudhury, K.Y. Ng, Preparation and evaluation of zinc-pectin-chitosan composite particles for drug delivery to the colon: role of chitosan in modifying in vitro and in vivo drug release, Int J Pharm 406(1-2) (2011) 11-20. ## [172] K. Kompany, E.H. Mirza, S. Hosseini, B. Pingguan-Murphy, I. Djordjevic, Polyoctanediol citrate–ZnO composite flms: Preparation, characterization and release kinetics of nanoparticles from polymer matrix, Materials Letters 126 (2014) 165-168. ## [173] A. Dodero, M. Alloisio, S. Vicini, M. Castellano, Preparation of composite alginate-based electrospun membranes loaded with ZnO nanoparticles, Carbohydrate polymers 227 (2020) 115371. ## [174] W. Artifon, S.M. Pasini, A. Valério, S.Y.G. González, S.M.d.A.G. Ulson, A.A.U. de Souza, Harsh environment resistant-antibacterial zinc oxide/Polyetherimide electrospun composite scaffolds, Materials Science and Engineering: C 103 (2019) 109859. ## [175] A. Bhattacharjee, M.K. Purkait, S. Gumma, Loading and release of doxorubicin hydrochloride from Iron (III) trimesate MOF and zinc oxide nanoparticle composites, Dalton Transactions (2020). ## [176] A.U. Kura, S.H.H. Al Ali, M.Z. Hussein, S. Fakurazi, P. Arulselvan, Development of a controlled-release anti-parkinsonian nanodelivery system using levodopa as the active agent, International Journal of Nanomedicine 8 (2013) 1103. ## [177] A. Seyfoori, S.A.S. Ebrahimi, S. Omidian, S.M. Naghib, Multifunctional magnetic ZnFe2O4-hydroxyapatite nanocomposite particles for local anti-cancer drug delivery and bacterial infection inhibition: An in vitro study, Journal of the Taiwan Institute of Chemical Engineers 96 (2019) 503-508. ## [178] A. Nigam, S.J. Pawar, Structural, magnetic, and antimicrobial properties of zinc doped magnesium ferrite for drug delivery applications, Ceramics International 46(4) (2020) 4058-4064. ## [179] Z. Neščáková, K. Zheng, L. Liverani, Q. Nawaz, D. Galusková, H. Kaňková, M. Michálek, D. Galusek, A.R. Boccaccini, Multifunctional zinc ion doped sol – gel derived mesoporous bioactive glass nanoparticles for biomedical applications, Bioactive Materials 4 (2019) 312-321. ## [180] V. Thangaraj, M. Yogapriya, K. Thirumalai, M. Swaminathan, A. Sundaramurthy, R. Nandhakumar, S. Suresh, E. Vakees, A. Araichimani, Sol–Gel Synthesis of Ce 4–xSr1+ xFe5–xZnxO14+δ ## [0≤ x≤ 0.45] Superparamagnetic Oxide Systems and Its Magnetic, Dielectric, and Drug Delivery Properties, ACS omega 3(12) (2018) 16509-16518. ## [181] D. Pathania, D. Gupta, N.C. Kothiyal, G. sharma, G.E. Eldesoky, M. Naushad, Preparation of a novel chitosan-g-poly(acrylamide)/Zn nanocomposite hydrogel and its applications for controlled drug delivery of ofloxacin, International Journal of Biological Macromolecules 84 (2016) 340-348. ## [182] M. Khatamian, B. Divband, F. Farahmand-Zahed, Synthesis and characterization of Zinc (II)-loaded Zeolite/Graphene oxide nanocomposite as a new drug carrier, Materials Science and Engineering: C 66 (2016) 251-258. ## [183] R. Rakhshaei, H. Namazi, H. Hamishehkar, H.S. Kafl, R. Salehi, In situ synthesized chitosan–gelatin/ZnO nanocomposite scaffold with drug delivery properties: Higher antibacterial and lower cytotoxicity effects, Journal of Applied Polymer Science 136(22) (2019) 47590. ## [184] M. Yadollahi, S. Farhoudian, S. Barkhordari, I. Gholamali, H. Farhadnejad, H. Motasadizadeh, Facile synthesis of chitosan/ZnO bio-nanocomposite hydrogel beads as drug delivery systems, International journal of biological macromolecules 82 (2016) 273-278. ## [185] Z. Yang, L. Wang, Y. Liu, S. Liu, D. Tang, L. Meng, B. Cui, ZnO capped flower-like porous carbon-Fe3O4 composite as carrier for bi-triggered drug delivery, Materials Science and Engineering: C 107 (2020) 110256. ## [186] F. Yang, X. Niu, X. Gu, C. Xu, W. Wang, Y. Fan, Biodegradable Magnesium-Incorporated Poly(l-lactic acid) Microspheres for Manipulation of Drug Release and Alleviation of Inflammatory Response, ACS Applied Materials and Interfaces 11(26) (2019) 23546-23557.204 F. Niazvand et al. / Journal of Composites and Compounds 2 (2020) 193-204 ## [187] M. Cheddadi, E. López-Cabarcos, K. Slowing, E. Barcia, A. Fernández-Carballido, Cytotoxicity and biocompatibility evaluation of a poly(magnesium acrylate) hydrogel synthesized for drug delivery, International Journal of Pharmaceutics 413(1) (2011) 126-133. ## [188] N.P. Rijal, U. Adhikari, N. Bhattarai, Magnesium Incorporated Polycaprolactone-Based Composite Nanofbers, ASME 2015 International Mechanical Engineering Congress and Exposition, 2015. ## [189] N.P. Rijal, U. Adhikari, S. Khanal, D. Pai, J. Sankar, N. Bhattarai, Magnesium oxide-poly(ε-caprolactone)-chitosan-based composite nanofber for tissue engineering applications, Materials Science and Engineering: B 228 (2018) 18-27. ## [190] F. Mohammad, T. Arfn, H.A. Al-Lohedan, Sustained drug release and electrochemical performance of ethyl cellulose-magnesium hydrogen phosphate composite, Materials Science and Engineering: C 71 (2017) 735-743. ## [191] F. Foroughi, S. Hassanzadeh-Tabrizi, A. Bigham, In situ microemulsion synthesis of hydroxyapatite-MgFe2O4 nanocomposite as a magnetic drug delivery system, Materials Science and Engineering: C 68 (2016) 774-779. ## [192] Z. Tabia, K. El Mabrouk, M. Bricha, K. Nouneh, Mesoporous bioactive glass nanoparticles doped with magnesium: drug delivery and acellular in vitro bioactivity, RSC advances 9(22) (2019) 12232-12246.200 F. Niazvand et al. / Journal of Composites and Compounds 2 (2020) 193-204 Carbohydrate polymers 150 (2016) 330-352. ## [8] F. Sharifanjazi, A.H. Pakseresht, M.S. Asl, A. Esmaeilkhanian, H.W. Jang, M. Shokouhimehr, Hydroxyapatite consolidated by zirconia: applications for dental implant, Journal of Composites and Compounds 2(1) (2020) 26-34. ## [9] L. Bazli, B. Eftekhari Yekta, A. Khavandi, Preparation and Characterization of Sn-Containing Glasses for Brachytherapy Applications, Transactions of the Indian Ceramic Society 76(4) (2017) 242-246. ## [10] Y. Kameshima, H. Sasaki, T. Isobe, A. Nakajima, K. Okada, Synthesis of composites of sodium oleate/Mg–Al-ascorbic acid-layered double hydroxides for drug delivery applications, International journal of pharmaceutics 381(1) (2009) 34-39. ## [11] M. Abniki, A. Moghimi, F. Azizinejad, Fabrication of bionanocomposite based on LDH using biopolymer of gum arabic and chitosan-coating for sustained drug-release, Journal of the Serbian Chemical Society 85(5) (2020). ## [12] M. Abniki, A. Moghimi, F. Azizinejad, Synthesis of calcium‐layered double hydroxide based nanohybrid for controlled release of an anti‐inflammatory drug, Journal of the Chinese Chemical Society (2020). ## [13] W.-H. Lu, K.-D. Li, C.-H. Lu, L.G. Teoh, W.H. Wu, Y.C. Shen, Synthesis and characterization of mesoporous SiO2–CaO–P2O5 bioactive glass by sol–gel process, Materials transactions 54(5) (2013) 791-795. ## [14] J. Andersson, S. Areva, B. Spliethoff, M. Lindén, Sol–gel synthesis of a multifunctional, hierarchically porous silica/apatite composite, Biomaterials 26(34) (2005) 6827-6835. ## [15] S.P. Hudson, R.F. Padera, R. Langer, D.S. Kohane, The biocompatibility of mesoporous silicates, Biomaterials 29(30) (2008) 4045-4055. ## [16] X. Li, X. Wang, H. Chen, P. Jiang, X. Dong, J. Shi, Hierarchically porous bioactive glass scaffolds synthesized with a PUF and P123 cotemplated approach, Chemistry of Materials 19(17) (2007) 4322-4326. ## [17] A. López-Noriega, D. Arcos, I. Izquierdo-Barba, Y. Sakamoto, O. Terasaki, M. Vallet-Regí, Ordered mesoporous bioactive glasses for bone tissue regeneration, Chemistry of Materials 18(13) (2006) 3137-3144. ## [18] X. Yan, X. Huang, C. Yu, H. Deng, Y. Wang, Z. Zhang, S. Qiao, G. Lu, D. Zhao, The in-vitro bioactivity of mesoporous bioactive glasses, Biomaterials 27(18) (2006) 3396-3403. ## [19] X. Yan, C. Yu, X. Zhou, J. Tang, D. Zhao, Highly ordered mesoporous bioactive glasses with superior in vitro bone‐forming bioactivities, Angewandte Chemie International Edition 43(44) (2004) 5980-5984. ## [20] M. Vašák, D.W. Hasler, Metallothioneins: new functional and structural insights, Current opinion in chemical biology 4(2) (2000) 177-183. ## [21] M.F. Heragh, S. Eskandarinezhad, A. Dehghan, Ni-Cu matrix composite reinforced with CNTs: preparation, characterization, wear and corrosion behavior, inhibitory effects, Journal of Composites and Compounds 2(4) (2020) 123-128. ## [22] C.T. Chasapis, A.C. Loutsidou, C.A. Spiliopoulou, M.E. Stefanidou, Zinc and human health: an update, Archives of toxicology 86(4) (2012) 521-534. ## [23] E. Alhava, H. Olkkonen, J. Puittinen, V. Nokso-Koivisto, Zinc content of human cancellous bone, Acta Orthopaedica Scandinavica 48(1) (1977) 1-4. ## [24] H. Kim, S. Mondal, S. Bharathiraja, P. Manivasagan, M.S. Moorthy, J. Oh, Optimized Zn-doped hydroxyapatite/doxorubicin bioceramics system for efcient drug delivery and tissue engineering application, Ceramics International 44(6) (2018) 6062-6071. ## [25] Y. Su, I. Cockerill, Y. Wang, Y.-X. Qin, L. Chang, Y. Zheng, D. Zhu, Zincbased biomaterials for regeneration and therapy, Trends in biotechnology 37(4) (2019) 428-441. ## [26] Z. Gao, D. Zhang, X. Li, S. Jiang, Q. Zhang, Current status, opportunities and challenges in chemical conversion coatings for zinc, Colloids and Surfaces A: Physicochemical and Engineering Aspects 546 (2018) 221-236. ## [27] S. Parveen, R. Misra, S.K. Sahoo, Nanoparticles: a boon to drug delivery, therapeutics, diagnostics and imaging, Nanomedicine: Nanotechnology, Biology and Medicine 8(2) (2012) 147-166. ## [28] H.M. Xiong, ZnO nanoparticles applied to bioimaging and drug delivery, Advanced Materials 25(37) (2013) 5329-5335. ## [29] Z.Y. Zhang, Y.D. Xu, Y.Y. Ma, L.L. Qiu, Y. Wang, J.L. Kong, H.M. Xiong, Biodegradable ZnO@ polymer core–shell nanocarriers: pH‐triggered release of doxorubicin in vitro, Angewandte Chemie 125(15) (2013) 4221-4225. ## [30] G. Song, Control of biodegradation of biocompatable magnesium alloys, Corrosion science 49(4) (2007) 1696-1701. ## [31] A.H. Shahbaz, M. Esmaeilian, R. NasrAzadani, K. Gavanji, The effect of MgF2 addition on the mechanical properties of hydroxyapatite synthesized via powder metallurgy, Journal of Composites and Compounds 1(1) (2019) 18-24. ## [32] S. Nasibi, K. Alimohammadi, L. Bazli, S. Eskandarinezhad, A. Mohammadi, N. Sheysi, TZNT alloy for surgical implant applications: A systematic review, Journal of Composites and Compounds 2(3) (2020) 62-68. ## [33] R. Erbel, C. Di Mario, J. Bartunek, J. Bonnier, B. de Bruyne, F.R. Eberli, P. Erne, M. Haude, B. Heublein, M. Horrigan, Temporary scaffolding of coronary arteries with bioabsorbable magnesium stents: a prospective, non-randomised multicentre trial, The Lancet 369(9576) (2007) 1869-1875. ## [34] M. Haude, R. Erbel, P. Erne, S. Verheye, H. Degen, D. Böse, P. Vermeersch, I. Wijnbergen, N. Weissman, F. Prati, Safety and performance of the drug-eluting absorbable metal scaffold (DREAMS) in patients with de-novo coronary lesions: 12 month results of the prospective, multicentre, frst-in-man BIOSOLVE-I trial, The Lancet 381(9869) (2013) 836-844. ## [35] M. Haude, H. Ince, A. Abizaid, R. Toelg, P.A. Lemos, C. von Birgelen, E.H. Christiansen, W. Wijns, F.-J. Neumann, C. Kaiser, Safety and performance of the second-generation drug-eluting absorbable metal scaffold in patients with de-novo coronary artery lesions (BIOSOLVE-II): 6 month results of a prospective, multicentre, non-randomised, frst-in-man trial, The Lancet 387(10013) (2016) 31-39. ## [36] B. Heublein, R. Rohde, V. Kaese, M. Niemeyer, W. Hartung, A. Haverich, Biocorrosion of magnesium alloys: a new principle in cardiovascular implant technology?, Heart 89(6) (2003) 651-656. ## [37] H. Li, H. Zhong, K. Xu, K. Yang, J. Liu, B. Zhang, F. Zheng, Y. Xia, L. Tan, D. Hong, Enhanced efcacy of sirolimus-eluting bioabsorbable magnesium alloy stents in the prevention of restenosis, Journal of Endovascular Therapy 18(3) (2011) 407-415. ## [38] R. Waksman, R. Erbel, C. Di Mario, J. Bartunek, B. de Bruyne, F.R. Eberli, P. Erne, M. Haude, M. Horrigan, C. Ilsley, Early-and long-term intravascular ultrasound and angiographic fndings after bioabsorbable magnesium stent implantation in human coronary arteries, JACC: Cardiovascular Interventions 2(4) (2009) 312-320. ## [39] R. Waksman, R. Pakala, P.K. Kuchulakanti, R. Baffour, D. Hellinga, R. Seabron, F.O. Tio, E. Wittchow, S. Hartwig, C. Harder, Safety and efcacy of bioabsorbable magnesium alloy stents in porcine coronary arteries, Catheterization and Cardiovascular Interventions 68(4) (2006) 607-617. ## [40] E. Wittchow, N. Adden, J. Riedmüller, C. Savard, R. Waksman, M. Braune, Bioresorbable drug-eluting magnesium-alloy scaffold: design and feasibility in a porcine coronary model, EuroIntervention 8(12) (2013) 1441-1450. ## [41] P. Zartner, R. Cesnjevar, H. Singer, M. Weyand, First successful implantation of a biodegradable metal stent into the left pulmonary artery of a preterm baby, Catheterization and Cardiovascular Interventions 66(4) (2005) 590-594. ## [42] M. Haude, H. Ince, A. Abizaid, R. Toelg, P.A. Lemos, C. von Birgelen, E.H. Christiansen, W. Wijns, F.-J. Neumann, C. Kaiser, Sustained safety and performance of the second-generation drug-eluting absorbable metal scaffold in patients with de novo coronary lesions: 12-month clinical results and angiographic fndings of the BIOSOLVE-II frst-in-man trial, European heart journal 37(35) (2016) 2701-2709. ## [43] M. Diba, O.-M. Goudouri, F. Tapia, A.R. Boccaccini, Magnesium-containing bioactive polycrystalline silicate-based ceramics and glass-ceramics for biomedical applications, Current opinion in solid state and materials science 18(3) (2014) 147-167. ## [44] Y. Bi, Y. Zheng, Y. Li, Microstructure and mechanical properties of sintered porous magnesium using polymethyl methacrylate as the space holder, Materials Letters 161 (2015) 583-586. ## [45] H. Bakhsheshi-Rad, E. Hamzah, M.P. Staiger, G.J. Dias, Z. Hadisi, M. Saheban, M. Kashefan, Drug release, cytocompatibility, bioactivity, and antibacterial activity of doxycycline loaded Mg-Ca-TiO2 composite scaffold, Materials and Design 139 (2018) 212-221. ## [46] K.K. Jain, Drug delivery systems-an overview, Drug delivery systems, Springer2008, pp. 1-50. ## [47] M. Arefan, M. Hojjati, I. Tajzad, A. Mokhtarzade, M. Mazhar, A. Jamavari, A review of Polyvinyl alcohol/Carboxiy methyl cellulose (PVA/CMC) composites for various applications, Journal of Composites and Compounds 2(3) (2020) 69- 76. ## [48] P. Abasian, M. Radmansouri, M.H. Jouybari, M.V. Ghasemi, A. Mohammadi, M. Irani, F.S. Jazi, Incorporation of magnetic NaX zeolite/DOX into the PLA/chitosan nanofbers for sustained release of doxorubicin against carcinoma cells death in vitro, International journal of biological macromolecules 121 (2019) 398-406. ## [49] H. Derendorf, L.J. Lesko, P. Chaikin, W.A. Colburn, P. Lee, R. Miller, R. Powell, G. Rhodes, D. Stanski, J. Venitz, Pharmacokinetic/pharmacodynamic modeling in drug research and development, The Journal of Clinical Pharmacology 40(12) (2000) 1399-1418. ## [50] S. Gopi, A. Amalraj, N.P. Sukumaran, J.T. Haponiuk, S. Thomas, Biopolymers and their composites for drug delivery: a brief review, Macromolecular Symposia, Wiley Online Library, 2018, p. 1800114. ## [51] G.R. Matzke, G.R. Aronoff, A.J. Atkinson Jr, W.M. Bennett, B.S. Decker, K.-U. Eckardt, T. Golper, D.W. Grabe, B. Kasiske, F. Keller, Drug dosing consideration in patients with acute and chronic kidney disease—a clinical update fromF. Niazvanda et al. / Journal of Composites and Compounds 2 (2020) 193-204 201 Kidney Disease: Improving Global Outcomes (KDIGO), Kidney international 80(11) (2011) 1122-1137. ## [52] M.J. Munoz-Davila, Role of old antibiotics in the era of antibiotic resistance. Highlighted nitrofurantoin for the treatment of lower urinary tract infections, Antibiotics 3(1) (2014) 39-48. ## [53] J.J. De Waele, S. Carrette, M. Carlier, V. Stove, J. Boelens, G. Claeys, I. Leroux-Roels, E. Hoste, P. Depuydt, J. Decruyenaere, Therapeutic drug monitoring-based dose optimisation of piperacillin and meropenem: a randomised controlled trial, Intensive care medicine 40(3) (2014) 380-387. ## [54] S.K. Bardal, J.E. Waechter, D.S. Martin, Applied pharmacology, Elsevier Health Sciences2011. ## [55] W. Brand, M.E. Schutte, G. Williamson, J.J. van Zanden, N.H. Cnubben, J.P. Groten, P.J. van Bladeren, I.M. Rietjens, Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients, Biomedicine and pharmacotherapy 60(9) (2006) 508-519. ## [56] A.H. Chow, H.H. Tong, P. Chattopadhyay, B.Y. Shekunov, Particle engineering for pulmonary drug delivery, Pharmaceutical research 24(3) (2007) 411-437. ## [57] S. Amirhossein, A.-B. Aydin, Z. Habib, Polaroid-PET: a PET scanner with detectors ftted with polaroids for fltering unpolarized optical photons: a Monte Carlo simulation study, Physics in Medicine and Biology (2020). ## [58] A. Sanaat, H. Zaidi, Depth of interaction estimation in a preclinical PET scanner equipped with monolithic crystals coupled to SiPMs using a deep neural network, Applied Sciences 10(14) (2020) 4753. ## [59] A. Sanaat, H. Arabi, M.R. Ay, H. Zaidi, Novel preclinical PET geometrical concept using a monolithic scintillator crystal offering concurrent enhancement in spatial resolution and detection sensitivity: a simulation study, Physics in Medicine and Biology 65(4) (2020) 045013. ## [60] A. Sanaat, H. Arabi, I. Mainta, V. Garibotto, H. Zaidi, Projection-space implementation of deep learning-guided low-dose brain PET imaging improves performance over implementation in image-space, Journal of Nuclear Medicine (2020) jnumed. 119.239327. ## [61] N. Kamaly, B. Yameen, J. Wu, O.C. Farokhzad, Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release, Chemical reviews 116(4) (2016) 2602-2663. ## [62] J. Daraei, Production and characterization of PCL (Polycaprolactone) coated TCP/nanoBG composite scaffolds by sponge foam method for orthopedic applications, Journal of Composites and Compounds 2(1) (2020) 45-50. ## [63] X. Huang, S. Wu, X. Ke, X. Li, X. Du, Phosphonated pillar ## [5] arene-valved mesoporous silica drug delivery systems, ACS Applied Materials and Interfaces 9(23) (2017) 19638-19645. ## [64] N.G. Kotla, B. Chandrasekar, P. Rooney, G. Sivaraman, A. Larrañaga, K.V. Krishna, A. Pandit, Y. Rochev, Biomimetic lipid-based nanosystems for enhanced dermal delivery of drugs and bioactive agents, ACS Biomaterials Science and Engineering 3(7) (2017) 1262-1272. ## [65] A. Kazemzadeh, H. Kazemzadeh, Determination of Hg2+ by Diphenylcarbazone Compound in Polymer Film, Journal of Composites and Compounds 1(1) (2019) 30-35. ## [66] A. Nouri, B. Faraji Dizaji, N. Kianinejad, A. Jafari Rad, S. Rahimi, M. Irani, F. Sharifan Jazi, Simultaneous linear release of folic acid and doxorubicin from ethyl cellulose/chitosan/g‐C3N4/MoS2 core‐shell nanofbers and its anticancer properties, Journal of Biomedical Materials Research Part A (2020). ## [67] D. Liu, F. Yang, F. Xiong, N. Gu, The smart drug delivery system and its clinical potential, Theranostics 6(9) (2016) 1306. ## [68] Z. Wang, Y. Duan, Y. Duan, Application of polydopamine in tumor targeted drug delivery system and its drug release behavior, Journal of Controlled Release 290 (2018) 56-74. ## [69] J. Ma, N. Zhao, D. Zhu, Endothelial cellular responses to biodegradable metal zinc, ACS biomaterials science and engineering 1(11) (2015) 1174-1182. ## [70] F.S. Jazi, N. Parvin, M. Rabiei, M. Tahriri, Z.M. Shabestari, A.R. Azadmehr, Effect of the synthesis route on the grain size and morphology of ZnO/Ag nanocomposite, Journal of Ceramic Processing Research 13(5) (2012) 523-526. ## [71] J. Jiang, J. Pi, J. Cai, The advancing of zinc oxide nanoparticles for biomedical applications, Bioinorganic chemistry and applications 2018 (2018). ## [72] Z. Zeng, X. Fang, W. Miao, Y. Liu, T. Maiyalagan, S. Mao, Electrochemically Sensing of Trichloroacetic Acid with Iron(II) Phthalocyanine and Zn-Based Metal Organic Framework Nanocomposites, ACS Sensors 4(7) (2019) 1934-1941. ## [73] W. Liu, Y. Pan, W. Xiao, H. Xu, D. Liu, F. Ren, X. Peng, J. Liu, Recent developments on zinc (ii) metal–organic framework nanocarriers for physiological pH-responsive drug delivery, MedChemComm 10(12) (2019) 2038-2051. ## [74] K. Dong, Y. Zhang, L. Zhang, Z. Wang, J. Ren, X. Qu, Facile preparation of metal− organic frameworks-based hydrophobic anticancer drug delivery nanoplatform for targeted and enhanced cancer treatment, Talanta 194 (2019) 703-708. ## [75] M. Zamani, M. Rostami, M. Aghajanzadeh, H. Kheiri Manjili, K. Rostamizadeh, H. Danafar, Mesoporous titanium dioxide@ zinc oxide–graphene oxide nanocarriers for colon-specifc drug delivery, Journal of Materials Science 53(3) (2018) 1634-1645. ## [76] J.W. Rasmussen, E. Martinez, P. Louka, D.G. Wingett, Zinc oxide nanoparticles for selective destruction of tumor cells and potential for drug delivery applications, Expert opinion on drug delivery 7(9) (2010) 1063-1077. ## [77] V. Karpina, V. Lazorenko, C. Lashkarev, V. Dobrowolski, L. Kopylova, V. Baturin, S. Pustovoytov, A.J. Karpenko, S. Eremin, P. Lytvyn, Zinc oxide–analogue of GaN with new perspective possibilities, Crystal Research and Technology: Journal of Experimental and Industrial Crystallography 39(11) (2004) 980-992. ## [78] X. Huang, X. Zheng, Z. Xu, C. Yi, Zno-based nanocarriers for drug delivery application: From passive to smart strategies, International journal of pharmaceutics 534(1-2) (2017) 190-194. ## [79] A.J. Rad, Synthesis of copper oxide nanoparticles on activated carbon for pollutant removal in Tartrazine structure, Journal of Composites and Compounds 2(3) (2020) 99-104. ## [80] A. Moghanian, A. Ghorbanoghli, M. Kazem‐Rostami, A. Pazhouheshgar, E. Salari, M. Saghaf Yazdi, T. Alimardani, H. Jahani, F. Sharifan Jazi, M. Tahriri, Novel antibacterial Cu/Mg‐substituted 58S‐bioglass: Synthesis, characterization and investigation of in vitro bioactivity, International Journal of Applied Glass Science 11(4) (2020) 685-698. ## [81] F. Sharifanjazi, M. Moradi, A. Abouchenari, A.H. Pakseresht, A. Esmaeilkhanian, M. Shokouhimehr, M.S. Asl, Effects of Sr and Mg dopants on biological and mechanical properties of SiO2–CaO–P2O5 bioactive glass, Ceramics International (2020). ## [82] S. Ni, L. Chou, J. Chang, Preparation and characterization of forsterite (Mg- 2SiO4) bioceramics, Ceramics International 33(1) (2007) 83-88. ## [83] N. Sezer, Z. Evis, S.M. Kayhan, A. Tahmasebifar, M. Koç, Review of magnesium-based biomaterials and their applications, Journal of Magnesium and Alloys 6(1) (2018) 23-43. ## [84] A. Bordbar-Khiabani, B. Yarmand, M. Mozafari, Emerging magnesium-based biomaterials for orthopedic implantation, Thomas Telford Ltd, 2019. ## [85] Z. Wu, T. Tang, H. Guo, S. Tang, Y. Niu, J. Zhang, W. Zhang, R. Ma, J. Su, C. Liu, In vitro degradability, bioactivity and cell responses to mesoporous magnesium silicate for the induction of bone regeneration, Colloids and Surfaces B: Biointerfaces 120 (2014) 38-46. ## [86] A. Bigham, S.A. Hassanzadeh-Tabrizi, M. Rafenia, H. Salehi, Ordered mesoporous magnesium silicate with uniform nanochannels as a drug delivery system: The effect of calcination temperature on drug delivery rate, Ceramics International 42(15) (2016) 17185-17191. ## [87] M. Vallet-Regi, Bio-ceramics with clinical applications, John Wiley and Sons2014. ## [88] P. Wu, D.W. Grainger, Drug/device combinations for local drug therapies and infection prophylaxis, Biomaterials 27(11) (2006) 2450-2467. ## [89] H. Dong, Q. Li, C. Tan, N. Bai, P. Cai, Bi-directional controlled release of ibuprofen and Mg2+ from magnesium alloys coated by multifunctional composite, Materials Science and Engineering: C 68 (2016) 512-518. ## [90] J. Tian, S. Shen, C. Zhou, X. Dang, Y. Jiao, L. Li, S. Ding, H. Li, Investigation of the antimicrobial activity and biocompatibility of magnesium alloy coated with HA and antimicrobial peptide, Journal of Materials Science: Materials in Medicine 26(2) (2015) 66. ## [91] J. Zhang, Z. Wen, M. Zhao, G. Li, C. Dai, Effect of the addition CNTs on performance of CaP/chitosan/coating deposited on magnesium alloy by electrophoretic deposition, Materials Science and Engineering: C 58 (2016) 992-1000. ## [92] A. Morawska-Chochół, P. Domalik-Pyzik, J. Chłopek, B. Szaraniec, J. Sterna, M. Rzewuska, M. Boguń, R. Kucharski, P. Mielczarek, Gentamicin release from biodegradable poly-l-lactide based composites for novel intramedullary nails, Materials Science and Engineering: C 45 (2014) 15-20. ## [93] A. Kazemzadeh, M.A. Meshkat, H. Kazemzadeh, M. Moradi, R. Bahrami, R. Pouriamanesh, Preparation of graphene nanolayers through surfactant-assisted pure shear milling method, Journal of Composites and Compounds 1(1) (2019) 25-30. ## [94] W.E. Teo, S. Ramakrishna, A review on electrospinning design and nanofbre assemblies, Nanotechnology 17(14) (2006) R89. ## [95] L.A. Mercante, V.P. Scagion, F.L. Migliorini, L.H. Mattoso, D.S. Correa, Electrospinning-based (bio) sensors for food and agricultural applications: A review, TrAC Trends in Analytical Chemistry 91 (2017) 91-103. ## [96] M. Jiménez, C. Abradelo, J. San Román, L. Rojo, Bibliographic review on the state of the art of strontium and zinc based regenerative therapies. Recent developments and clinical applications, Journal of materials chemistry B 7(12) (2019)202 F. Niazvand et al. / Journal of Composites and Compounds 2 (2020) 193-204 1974-1985. ## [97] T.J. Sill, H.A. Von Recum, Electrospinning: applications in drug delivery and tissue engineering, Biomaterials 29(13) (2008) 1989-2006. ## [98] Y. Qian, Solvothermal Synthesis of Nanocrystalline III–V Semiconductors, Advanced Materials 11(13) (1999) 1101-1102. ## [99] C. Wang, Z.-X. Deng, Y. Li, The synthesis of nanocrystalline anatase and rutile titania in mixed organic media, Inorganic Chemistry 40(20) (2001) 5210-5214. ## [100] K. Kaviyarasu, E. Manikandan, P. Paulraj, S. Mohamed, J. Kennedy, One dimensional well-aligned CdO nanocrystal by solvothermal method, Journal of alloys and compounds 593 (2014) 67-70. ## [101] C.-S. Kim, B.K. Moon, J.-H. Park, S. Tae Chung, S.-M. Son, Synthesis of nanocrystalline TiO2 in toluene by a solvothermal route, Journal of Crystal Growth 254(3) (2003) 405-410. ## [102] M. Kang, Synthesis of Fe/TiO2 photocatalyst with nanometer size by solvothermal method and the effect of H 2O addition on structural stability and photodecomposition of methanol, Journal of Molecular Catalysis A: Chemical 197(1) (2003) 173-183. ## [103] S. Yin, Y. Fujishiro, J. Wu, M. Aki, T. Sato, Synthesis and photocatalytic properties of fbrous titania by solvothermal reactions, Journal of Materials Processing Technology 137(1-3) (2003) 45-48. ## [104] S.M. Gupta, M. Tripathi, A review on the synthesis of TiO2 nanoparticles by solution route, Central European Journal of Chemistry 10(2) (2012) 279-294. ## [105] F.L. Theiss, G.A. Ayoko, R.L. Frost, Synthesis of layered double hydroxides containing Mg2+, Zn2+, Ca2+ and Al3+ layer cations by co-precipitation methods—A review, Applied Surface Science 383 (2016) 200-213. ## [106] M. Bukhtiyarova, A review on effect of synthesis conditions on the formation of layered double hydroxides, Journal of Solid State Chemistry 269 (2019) 494-506. ## [107] V. Solovov, N. Nikolenko, V. Kovalenko, V. Kotok, A. Burkov, D. Kondrat’ev, O. Chernovа, S. Zhukovin, Synthesis of Ni (II)-Ti (IV) layered double hydroxides using coprecipitation at high supersaturation method, ARPN Journal of Engineering and Applied Sciences 13(24) (2018) 9652-9656. ## [108] X. Duan, D.G. Evans, Layered double hydroxides, Springer Science and Business Media2006. ## [109] H.W. Olfs, L.O. Torres-Dorante, R. Eckelt, H. Kosslick, Comparison of different synthesis routes for Mg–Al layered double hydroxides (LDH): Characterization of the structural phases and anion exchange properties, Applied Clay Science 43(3) (2009) 459-464. ## [110] L. Bazli, M. Siavashi, A. Shiravi, A review of carbon nanotube/TiO2 composite prepared via sol-gel method, Journal of Composites and Compounds 1(1) (2019) 1-9. ## [111] A. Bakhtiari, A. Cheshmi, M. Naeimi, S.M. Fathabad, M. Aliasghari, A.M. Chahardehi, S. Hassani, V. Elhami, Synthesis and characterization of the novel 80S bioactive glass: bioactivity,‎ biocompatibility, cytotoxicity, Journal of Composites and Compounds 2(4) (2020) 110-114. ## [112] L. Armelao, D. Barreca, M. Bertapelle, G. Bottaro, C. Sada, E. Tondello, A sol–gel approach to nanophasic copper oxide thin flms, Thin Solid Films 442(1) (2003) 48-52. ## [113] F.S. Jazi, N. Parvin, M. Tahriri, M. Alizadeh, S. Abedini, M. Alizadeh, The relationship between the synthesis and morphology of SnO2-Ag2O nanocomposite, Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry 44(5) (2014) 759-764. ## [114] M. Alizadeh, F. Sharifanjazi, E. Haghshenasjazi, M. Aghakhani, L. Rajabi, Production of nanosized boron oxide powder by high-energy ball milling, Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry 45(1) (2015) 11-14. ## [115] L.S. Cividanes, T.M. Campos, L.A. Rodrigues, D.D. Brunelli, G.P. Thim, Review of mullite synthesis routes by sol–gel method, Journal of Sol-Gel Science and Technology 55(1) (2010) 111-125. ## [116] M. Gonçalves, Sol-gel silica nanoparticles in medicine: A natural choice. Design, synthesis and products, Molecules 23(8) (2018) 2021. ## [117] S. Devaraju, K. Krishnadevi, E. Naveena, M. Alagar, Eco-friendly fully bio-based polybenzoxazine-silica hybrid materials by sol–gel approach, Polymer Bulletin (2020) 1-10. ## [118] H. Böttcher, P. Slowik, W. Süß, Sol-gel carrier systems for controlled drug delivery, Journal of sol-gel science and technology 13(1-3) (1998) 277-281. ## [119] M. Catauro, E. Tranquillo, F. Barrino, I. Blanco, F. Dal Poggetto, D. Naviglio, Drug release of hybrid materials containing Fe (II) citrate synthesized by sol-gel technique, Materials 11(11) (2018) 2270. ## [120] Y. Ding, W. Li, A. Correia, Y. Yang, K. Zheng, D. Liu, D.W. Schubert, A.R. Boccaccini, H.A. Santos, J.A. Roether, Electrospun polyhydroxybutyrate/poly (ε-caprolactone)/Sol–gel-derived silica hybrid scaffolds with drug releasing function for bone tissue engineering applications, ACS applied materials and interfaces 10(17) (2018) 14540-14548. ## [121] M. Catauro, F. Barrino, G. Dal Poggetto, M. Milazzo, I. Blanco, S.V. Ciprioti, Structure, drug absorption, bioactive and antibacterial properties of sol-gel SiO2/ ZrO 2 materials, Ceramics International (2020). ## [122] S.K. Sahoo, S. Barik, G. Dehury, S. Dhala, S. Kanungo, B.B. Barik, K.K. Puhan, Evaluation of controlled release theophylline microspheres prepared with cellulose acetate using solvent evaporation method, Tropical Journal of Pharmaceutical Research 10(2) (2011). ## [123] S. Jaraswekin, S. Prakongpan, R. Bodmeier, Effect of poly (lactide-co-glycolide) molecular weight on the release of dexamethasone sodium phosphate from microparticles, Journal of microencapsulation 24(2) (2007) 117-128. ## [124] S. Freitas, H.P. Merkle, B. Gander, Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology, Journal of Controlled Release 102(2) (2005) 313-332. ## [125] J. Emami, H. Hamishehkar, A.R. Najafabadi, K. Gilani, M. Minaiyan, H. Mahdavi, A. Nokhodchi, A Novel Approach to Prepare Insulin-Loaded Poly (Lactic-Co-Glycolic Acid) Microcapsules and the Protein Stability Study, Journal of Pharmaceutical Sciences 98(5) (2009) 1712-1731. ## [126] M.L. Manca, Chitosan and PLGA microspheres as drug delivery system against pulmonary mycobacteria infections, (2007). ## [127] M. Hoppel, D. Mahrhauser, C. Stallinger, F. Wagner, M. Wirth, C. Valenta, Natural polymer‐stabilized multiple water‐in‐oil‐in‐water emulsions: a novel dermal drug delivery system for 5‐fluorouracil, Journal of Pharmacy and Pharmacology 66(5) (2014) 658-667. ## [128] H. Yang, Y. Hao, Q. Liu, Z. Mi, Z. Wang, L. Zhu, Q. Feng, N. Hu, Preparation and in vitro study of hydrochloric norvancomycin encapsulated poly (d, l-lactide-co-glycolide, PLGA) microspheres for potential use in osteomyelitis, Artifcial cells, nanomedicine, and biotechnology 45(7) (2017) 1326-1330. ## [129] M. Li, O. Rouaud, D. Poncelet, Microencapsulation by solvent evaporation: State of the art for process engineering approaches, International Journal of Pharmaceutics 363(1) (2008) 26-39. ## [130] W.M. Obeidat, Recent patents review in microencapsulation of pharmaceuticals using the emulsion solvent removal methods, Recent patents on drug delivery and formulation 3(3) (2009) 178-192. ## [131] Y. Maa, C. Hsu, Effect of primary emulsions on microsphere size and protein-loading in the double emulsion process, Journal of microencapsulation 14(2) (1997) 225-241. ## [132] D. Noviendri, Microencapsulation of Fucoxanthin by Water-in-Oil-in-Water (W/O/W) Double Emulsion Solvent Evaporation Method: A Review, Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology 9(3) (2014). ## [133] Y.-Y. Yang, T.-S. Chung, N.P. Ng, Morphology, drug distribution, and in vitro release profles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method, Biomaterials 22(3) (2001) 231-241. ## [134] R. Zhang, L. Gao, Preparation of nanosized titania by hydrolysis of alkoxide titanium in micelles, Materials research bulletin 37(9) (2002) 1659-1666. ## [135] A.S. Narang, D. Delmarre, D. Gao, Stable drug encapsulation in micelles and microemulsions, International journal of pharmaceutics 345(1-2) (2007) 9-25. ## [136] M.A. Malik, M.Y. Wani, M.A. Hashim, Microemulsion method: A novel route to synthesize organic and inorganic nanomaterials: 1st Nano Update, Arabian Journal of Chemistry 5(4) (2012) 397-417. ## [137] S.F. Chin, A. Azman, S.C. Pang, Size Controlled Synthesis of Starch Nanoparticles by a Microemulsion Method, Journal of Nanomaterials 2014 (2014) 763736. ## [138] H. Liu, J. Mei, Y. Xu, L. Tang, D. Chen, Y. Zhu, S. Huang, T.J. Webster, H. Ding, Improving The Oral Absorption Of Nintedanib By A Self-Microemulsion Drug Delivery System: Preparation And In Vitro/In Vivo Evaluation, International Journal of Nanomedicine 14 (2019) 8739. ## [139] M.B. de Jesus, A. Radaic, I.S. Zuhorn, E. de Paula, Microemulsion extrusion technique: a new method to produce lipid nanoparticles, Journal of nanoparticle research 15(10) (2013) 1960. ## [140] S.P. Callender, J.A. Mathews, K. Kobernyk, S.D. Wettig, Microemulsion utility in pharmaceuticals: Implications for multi-drug delivery, International journal of pharmaceutics 526(1-2) (2017) 425-442. ## [141] B. Yan, Y. Gu, J. Zhao, Y. Liu, L. Wang, Y. Wang, Self-microemulsion Technology for Water-insoluble Drug Delivery, Current Nanoscience 15(6) (2019) 576- 588. ## [142] S.M. Dizaj, F. Lotfpour, M. Barzegar-Jalali, M.-H. Zarrintan, K. Adibkia, Physicochemical characterization and antimicrobial evaluation of gentamicin-loaded CaCO 3 nanoparticles prepared via microemulsion method, Journal of Drug Delivery Science and Technology 35 (2016) 16-23.F. Niazvanda et al. / Journal of Composites and Compounds 2 (2020) 193-204 203 ## [143] M.N. Kelchen, N.K. Brogden, In vitro skin retention and drug permeation through intact and microneedle pretreated skin after application of propranolol loaded microemulsions, Pharmaceutical research 35(12) (2018) 228. ## [144] L. Huang, J. Wu, M. Liu, L. Mao, H. Huang, Q. Wan, Y. Dai, Y. Wen, X. Zhang, Y. Wei, Direct surface grafting of mesoporous silica nanoparticles with phospholipid choline-containing copolymers through chain transfer free radical polymerization and their controlled drug delivery, Journal of colloid and interface science 508 (2017) 396-404. ## [145] L.J. Min, T.Y.S. Edgar, Z. Zicheng, Y.W. Yee, Chapter 6 - Biomaterials for Bioprinting, in: L.G. Zhang, J.P. Fisher, K.W. Leong (Eds.), 3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine, Academic Press2015, pp. 129-148. ## [146] Z. Shi, C. Yang, R. Li, L. Ruan, Microwave thermal-triggered drug delivery using thermosensitive peptide-coated core–shell mesoporous silica nanoparticles, Journal of Materials Science 55(14) (2020) 6118-6129. ## [147] R.E. Mardziah, T.W. Wong, Effects of microwave on drug-release responses of spray-dried alginate microspheres, Drug development and industrial pharmacy 36(10) (2010) 1149-1167. ## [148] T. Wong, Use of microwave in processing of drug delivery systems, Current Drug Delivery 5(2) (2008) 77-84. ## [149] H. Qiu, B. Cui, W. Zhao, P. Chen, H. Peng, Y. Wang, A novel microwave stimulus remote controlled anticancer drug release system based on Fe3O4@ZnO@ mGd 2O3: Eu@P(NIPAm-co-MAA) multifunctional nanocarriers, Journal of Materials Chemistry B 3(34) (2015) 6919-6927. ## [150] J. Xu, X. Cheng, L. Tan, C. Fu, M. Ahmed, J. Tian, J. Dou, Q. Zhou, X. Ren, Q. Wu, Microwave responsive nanoplatform via P-selectin mediated drug delivery for treatment of hepatocellular carcinoma with distant metastasis, Nano letters 19(5) (2019) 2914-2927. ## [151] S. Miyazaki, H. Aoyama, N. Kawasaki, W. Kubo, D. Attwood, In situ-gelling gellan formulations as vehicles for oral drug delivery, Journal of Controlled release 60(2-3) (1999) 287-295. ## [152] Y. Wu, Y. Liu, X. Li, D. Kebebe, B. Zhang, J. Ren, J. Lu, J. Li, S. Du, Z. Liu, Research progress of in-situ gelling ophthalmic drug delivery system, Asian Journal of Pharmaceutical Sciences 14(1) (2019) 1-15. ## [153] M. Agrawal, S. Saraf, S. Saraf, S.K. Dubey, A. Puri, U. Gupta, P. Kesharwani, V. Ravichandiran, P. Kumar, V. Naidu, Stimuli-responsive In situ gelling system for nose-to-brain drug delivery, Journal of Controlled Release (2020). ## [154] K. Itoh, T. Hirayama, A. Takahashi, W. Kubo, S. Miyazaki, M. Dairaku, M. Togashi, R. Mikami, D. Attwood, In situ gelling pectin formulations for oral drug delivery at high gastric pH, International journal of pharmaceutics 335(1-2) (2007) 90-96. ## [155] T.N. Nimi, D.R. Manohar, An Overview on In-Situ Nasal Gel for Drug Delivery, Journal of Pharmaceutical Sciences and Research 11(7) (2019) 2585-2589. ## [156] S. Desai, S. Bolton, A floating controlled-release drug delivery system: in vitro-in vivo evaluation, Pharmaceutical research 10(9) (1993) 1321-1325. ## [157] Z. Shi, X. Chen, L. Zhang, S. Ding, X. Wang, Q. Lei, W. Fang, FA-PEG decorated MOF nanoparticles as a targeted drug delivery system for controlled release of an autophagy inhibitor, Biomaterials science 6(10) (2018) 2582-2590. ## [158] K. Neha, H.S. Nirmala, Insitu gelling system: A Review, J Drug Del and Therapeutics 4(4) (2014) 93-103. ## [159] P. Suradkar, R. Mishra, T. Nandgude, Overview on Trends in Development of Gastroretentive Drug Delivery System, Research Journal of Pharmacy and Technology 12(11) (2019) 5633-5640. ## [160] D. Bhowmik, R. Bhanot, D. Gautam, P. Rai, K. Kumar, Gastro Retentive Drug Delivery Systems-a Novel Approaches of Controlled Drug Delivery Systems, Research Journal of Science and Technology 10(2) (2018) 145-156. ## [161] S. Fredenberg, M. Wahlgren, M. Reslow, A. Axelsson, The mechanisms of drug release in poly (lactic-co-glycolic acid)-based drug delivery systems—a review, International journal of pharmaceutics 415(1-2) (2011) 34-52. ## [162] J. Panyam, V. Labhasetwar, Biodegradable nanoparticles for drug and gene delivery to cells and tissue, Advanced drug delivery reviews 55(3) (2003) 329-347. ## [163] Y. Ma, J.C. Pacan, Q. Wang, Y. Xu, X. Huang, A. Korenevsky, P.M. Sabour, Microencapsulation of bacteriophage Felix O1 into chitosan-alginate microspheres for oral delivery, Applied and environmental microbiology 74(15) (2008) 4799- 4805. ## [164] J. Trygg, E. Yildir, R. Kolakovic, N. Sandler, P. Fardim, Anionic cellulose beads for drug encapsulation and release, Cellulose 21(3) (2014) 1945-1955. ## [165] H. Bao, Y. Pan, Y. Ping, N.G. Sahoo, T. Wu, L. Li, J. Li, L.H. Gan, Chitosan‐ functionalized graphene oxide as a nanocarrier for drug and gene delivery, Small 7(11) (2011) 1569-1578. ## [166] S. Javanbakht, M. Pooresmaeil, H. Namazi, Green one-pot synthesis of carboxymethylcellulose/Zn-based metal-organic framework/graphene oxide bio-nanocomposite as a nanocarrier for drug delivery system, Carbohydrate Polymers 208 (2019) 294-301. ## [167] H.H.P. Duong, L.-Y.L. Yung, Synergistic co-delivery of doxorubicin and paclitaxel using multi-functional micelles for cancer treatment, International journal of pharmaceutics 454(1) (2013) 486-495. ## [168] F. Foroughi, S.A. Hassanzadeh-Tabrizi, A. Bigham, In situ microemulsion synthesis of hydroxyapatite-MgFe2O4 nanocomposite as a magnetic drug delivery system, Materials Science and Engineering: C 68 (2016) 774-779. ## [169] K. Drlica, Biology of bacterial deoxyribonucleic acid topoisomerases, Microbiological reviews 48(4) (1984) 273. ## [170] D. Pathania, D. Gupta, N. Kothiyal, G. Eldesoky, M. Naushad, Preparation of a novel chitosan-g-poly (acrylamide)/Zn nanocomposite hydrogel and its applications for controlled drug delivery of ofloxacin, International journal of biological macromolecules 84 (2016) 340-348. ## [171] S. Das, A. Chaudhury, K.Y. Ng, Preparation and evaluation of zinc-pectin-chitosan composite particles for drug delivery to the colon: role of chitosan in modifying in vitro and in vivo drug release, Int J Pharm 406(1-2) (2011) 11-20. ## [172] K. Kompany, E.H. Mirza, S. Hosseini, B. Pingguan-Murphy, I. Djordjevic, Polyoctanediol citrate–ZnO composite flms: Preparation, characterization and release kinetics of nanoparticles from polymer matrix, Materials Letters 126 (2014) 165-168. ## [173] A. Dodero, M. Alloisio, S. Vicini, M. Castellano, Preparation of composite alginate-based electrospun membranes loaded with ZnO nanoparticles, Carbohydrate polymers 227 (2020) 115371. ## [174] W. Artifon, S.M. Pasini, A. Valério, S.Y.G. González, S.M.d.A.G. Ulson, A.A.U. de Souza, Harsh environment resistant-antibacterial zinc oxide/Polyetherimide electrospun composite scaffolds, Materials Science and Engineering: C 103 (2019) 109859. ## [175] A. Bhattacharjee, M.K. Purkait, S. Gumma, Loading and release of doxorubicin hydrochloride from Iron (III) trimesate MOF and zinc oxide nanoparticle composites, Dalton Transactions (2020). ## [176] A.U. Kura, S.H.H. Al Ali, M.Z. Hussein, S. Fakurazi, P. Arulselvan, Development of a controlled-release anti-parkinsonian nanodelivery system using levodopa as the active agent, International Journal of Nanomedicine 8 (2013) 1103. ## [177] A. Seyfoori, S.A.S. Ebrahimi, S. Omidian, S.M. Naghib, Multifunctional magnetic ZnFe2O4-hydroxyapatite nanocomposite particles for local anti-cancer drug delivery and bacterial infection inhibition: An in vitro study, Journal of the Taiwan Institute of Chemical Engineers 96 (2019) 503-508. ## [178] A. Nigam, S.J. Pawar, Structural, magnetic, and antimicrobial properties of zinc doped magnesium ferrite for drug delivery applications, Ceramics International 46(4) (2020) 4058-4064. ## [179] Z. Neščáková, K. Zheng, L. Liverani, Q. Nawaz, D. Galusková, H. Kaňková, M. Michálek, D. Galusek, A.R. Boccaccini, Multifunctional zinc ion doped sol – gel derived mesoporous bioactive glass nanoparticles for biomedical applications, Bioactive Materials 4 (2019) 312-321. ## [180] V. Thangaraj, M. Yogapriya, K. Thirumalai, M. Swaminathan, A. Sundaramurthy, R. Nandhakumar, S. Suresh, E. Vakees, A. Araichimani, Sol–Gel Synthesis of Ce 4–xSr1+ xFe5–xZnxO14+δ ## [0≤ x≤ 0.45] Superparamagnetic Oxide Systems and Its Magnetic, Dielectric, and Drug Delivery Properties, ACS omega 3(12) (2018) 16509-16518. ## [181] D. Pathania, D. Gupta, N.C. Kothiyal, G. sharma, G.E. Eldesoky, M. Naushad, Preparation of a novel chitosan-g-poly(acrylamide)/Zn nanocomposite hydrogel and its applications for controlled drug delivery of ofloxacin, International Journal of Biological Macromolecules 84 (2016) 340-348. ## [182] M. Khatamian, B. Divband, F. Farahmand-Zahed, Synthesis and characterization of Zinc (II)-loaded Zeolite/Graphene oxide nanocomposite as a new drug carrier, Materials Science and Engineering: C 66 (2016) 251-258. ## [183] R. Rakhshaei, H. Namazi, H. Hamishehkar, H.S. Kafl, R. Salehi, In situ synthesized chitosan–gelatin/ZnO nanocomposite scaffold with drug delivery properties: Higher antibacterial and lower cytotoxicity effects, Journal of Applied Polymer Science 136(22) (2019) 47590. ## [184] M. Yadollahi, S. Farhoudian, S. Barkhordari, I. Gholamali, H. Farhadnejad, H. Motasadizadeh, Facile synthesis of chitosan/ZnO bio-nanocomposite hydrogel beads as drug delivery systems, International journal of biological macromolecules 82 (2016) 273-278. ## [185] Z. Yang, L. Wang, Y. Liu, S. Liu, D. Tang, L. Meng, B. Cui, ZnO capped flower-like porous carbon-Fe3O4 composite as carrier for bi-triggered drug delivery, Materials Science and Engineering: C 107 (2020) 110256. ## [186] F. Yang, X. Niu, X. Gu, C. Xu, W. Wang, Y. Fan, Biodegradable Magnesium-Incorporated Poly(l-lactic acid) Microspheres for Manipulation of Drug Release and Alleviation of Inflammatory Response, ACS Applied Materials and Interfaces 11(26) (2019) 23546-23557.204 F. Niazvand et al. / Journal of Composites and Compounds 2 (2020) 193-204 ## [187] M. Cheddadi, E. López-Cabarcos, K. Slowing, E. Barcia, A. Fernández-Carballido, Cytotoxicity and biocompatibility evaluation of a poly(magnesium acrylate) hydrogel synthesized for drug delivery, International Journal of Pharmaceutics 413(1) (2011) 126-133. ## [188] N.P. Rijal, U. Adhikari, N. Bhattarai, Magnesium Incorporated Polycaprolactone-Based Composite Nanofbers, ASME 2015 International Mechanical Engineering Congress and Exposition, 2015. ## [189] N.P. Rijal, U. Adhikari, S. Khanal, D. Pai, J. Sankar, N. Bhattarai, Magnesium oxide-poly(ε-caprolactone)-chitosan-based composite nanofber for tissue engineering applications, Materials Science and Engineering: B 228 (2018) 18-27. ## [190] F. Mohammad, T. Arfn, H.A. Al-Lohedan, Sustained drug release and electrochemical performance of ethyl cellulose-magnesium hydrogen phosphate composite, Materials Science and Engineering: C 71 (2017) 735-743. ## [191] F. Foroughi, S. Hassanzadeh-Tabrizi, A. Bigham, In situ microemulsion synthesis of hydroxyapatite-MgFe2O4 nanocomposite as a magnetic drug delivery system, Materials Science and Engineering: C 68 (2016) 774-779. ## [192] Z. Tabia, K. El Mabrouk, M. Bricha, K. Nouneh, Mesoporous bioactive glass nanoparticles doped with magnesium: drug delivery and acellular in vitro bioactivity, RSC advances 9(22) (2019) 12232-12246.