1 Fabrication of Composite-Based Biosensors for Rapid Disease Detection 1 Biosensors are a fundamental component of point-of-care diagnostic technologies, which are essential for early detection and real-time health monitoring. They play a vital role in improving healthcare outcomes and making a significant societal impact by facilitating rapid diagnostics and disease management. This review explores the fundamentals of biosensors, including theiroperational principles, key components, and mechanisms, as well as the use of composite materials and their applications in disease detection. Furthermore, it discusses important performance metrics such as sensitivity, specificity, stability, and reproducibility. 1 6 Mehrasa Nikandish King’s College LondonFaculty of Life Science and Medicine King’s College London, London UK K21221255@kcl.ac.uk Hawraa Alsayegh King’s College LondonFaculty of Life Science and Medicine King’s College London, London UK K23104146@kcl.ac.uk Mojtaba Karbalaee Shoushtar Faculty of Medical Sciences, Shoushtar Iran mehdikarbalaee99@gmail.com Narjes Sadat Yadollahi Nooshabadi Department of Psychiatric Nursing, School of Nursing and Midwifery, Kashan University of Medical Sciences, Kashan Iran yadollahi.nurse@gmail.com Mohammad Borhan Abazari Department of Biotechnology, University of Tehran, Tehran Iran Borhanabazari@ut.ac.ir Biosensors Composites Diseases Detection Early Diagnosis [1] K.M. Tripathi, T. Kim, D. Losic, T.T. 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