https://doi.org/10.61186/jcc.6.4.1 1 Biomedical applications of copper nanoparticles: an up-to-date overview 1 Copper nanoparticles (CuNPs) have garnered significant attention in biomedicine due to their various properties and potential applications. These nanoparticles exhibit promising antimicrobial, anticancer, and antioxidant activities, which enhance their value in nanomedicine applications. Their properties, shaped by the fabrication techniques, facilitate their application in drug delivery, cancer therapy, tissue engineering, and dental applications uses. Nevertheless, obstacles persist in attaining biocompatibility and regulated release, which are vital for effective clinical transference. Toxicological evaluations are essential to ensure the secure utilization of CuNPs. Additionally, studies are ongoing to find creative solutions to address these challenges and fully harness the medical potential of CuNPs. 1 8 Negin Khosravi School of Science and Health, The University of Georgia, Tbilisi. Georgia neginkh.std@ug.edu.ge Alaa Alzufairi Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University Kuwait Alaa_alzufairi@hotmail.com Parisa Zahed Iran University of Medical Sciences, Finetech in Medicine Research Center, Iran University of Medical Sciences, Tehran. Iran parisazahed1376@gmail.com Aliasghar Abouchenari Materials Engineering, Shahid Bahonar University, Kerman. Iran aliab596@yahoo.com Sohrab Asgaran Helmaco Sp. Z o.o. Company, Ostrobramska 101 / 335K, 04-041 Warsaw. Poland S.a@helmaco.com Setareh Reza-Soltani Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Science (TUMS), Tehran. Iran s-rezasoltani@alumnus.tums.ac.ir Zahra Moazzami Goudarzi Laboratory of Polymers and Biomaterials, Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawinskiego 5B, Warsaw, 02–106 Poland. Poland zmoazami@ippt.pan.pl Copper nanoparticles Antibacterial Synthesis Biocompatibility Biomedical applications Article.pdf [1] S. Malik, K. Muhammad, Y. Waheed, Nanotechnology: A Revolution in Modern Industry, Molecules, 2023. ##[2] S. Bahadori, M. Azimpour, Advancements in Nanoparticle-Supported Laccase Immobilization: Promising Solutions for Water Treatment, Journal of Composites and Compounds 5(16) (2023) 159-178 DOI: 10.61186/jcc.5.3.2.##[3] J. Varshosaz, Advancements in Nanostructured Drug Delivery Systems: A Commentary on Multifunctional Approaches for Cancer and Inflammatory Disease Treatment, Journal of Composites and Compounds 5(16) (2023) 210-211 .##[4] X. Geng, K. Liu, J. Wang, X. Su, Y. Shi, L. 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